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‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

 

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Peter I Parry 1 2, Astrid Lefringhausen 3, Conny Turni 4, Christopher J Neil 5, Robyn Cosford 3, Nicholas J Hudson 6, Julian Gillespie 3
Affiliations 

 

Abstract

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely

 

Key Points

  • Highly safe and effective vaccines are central to combat infectious disease epidemics/pandemics.
  • SARS-CoV-2 spike protein is pathogenic, whether from the virus or created from genetic code in mRNA and adenovectorDNA vaccines.
  • Biodistribution rodent study data show lipid nanoparticles carry mRNA to all organs and cross blood-brain and blood-placenta barriers. Some of these tissues are likely to be impervious to viral infection; therefore, the biohazard is particularly from vaccination.
  • Lipid-nanoparticles have inflammatory properties.
  • The modification of mRNA with N1-methylpseudouridine for increased stability leads to the production of spike proteins for months. It is uncertain how many cells and from which organs mRNA spike proteins are produced, and therefore, the exact effective dose delivered per vaccine vial is unknown.
  • The long-term fate of mRNA within cells is currently unknown.
  • The mRNA and adenovectorDNA vaccines act as ‘synthetic viruses’.
  • In the young and healthy, and even in many older individuals with vulnerable comorbidities, the encoding-based COVID-19 vaccines will likely transfect a far more diverse set of tissues than infection by the virus itself.
  • Evidence suggests reverse transcription of mRNA into a DNA copy is possible. This further suggests the possibility of intergenerational transmission if germline cells incorporate the DNA copy into the host genome.
  • Production of foreign proteins such as spike protein on cell surfaces can induce autoimmune responses and tissue damage. This has profoundly negative implications for any future mRNA-based drug or vaccine.
  • The spike protein exerts its pathophysiological effects (‘spikeopathy’) via several mechanisms that lead to inflammation, thrombogenesis, and endotheliitis-related tissue damage and prion-related dysregulation.
  • Interaction of the vaccine-encoded spike protein with ACE-2, P53 and BRCA1 suggests a wide range of possible biological interference with oncological potential.
  • Adverse event data from official pharmacovigilance databases, an FDA-Pfizer report obtained via FOI, show high rates and multiple organ systems affected: primarily neurological, cardiovascular, and reproductive.
  • Pfizer and Moderna mRNA COVID-19 vaccines’ clinical trial data independently interpreted has been peer-review and published to show an unfavourable risk/benefit, especially in the non-elderly. The risks for children clearly outweigh the benefits.
  • Repeated COVID-19 vaccine booster doses appear to induce tolerance and may contribute to recurrent COVID-19 infection and ‘long COVID’.
  • The SARS-CoV-2 pandemic has revealed deficiencies in public health and medicines regulatory agencies.
  • A root cause analysis is needed for what now appears a rushed response to an alarming infectious disease pandemic.
  • Treatment modalities for ‘spikeopathy’-related pathology in many organ systems, require urgent research and provision to millions of sufferers of long-term COVID-19 vaccine injuries.

Free PMC article

THE MEDICINE PARADIGM HAS CHANGED

The paradigm of Medicine,”Medical Education” and medical science have changed. These are the results of the two historic World Congresses promoted by Ambrosiana University, in streaming, concluded on June 23 under the patronage of the European Parliament and the Pontifical Academy of Sciences.

The Paradigm Change of Medicine: the epistemological and scientific basis of Person-Centered Medicine

(21-22 June)

and

Person-Centered Medicine: the medicine and health paradigm change in medical science and medical education

(23 June)

The conference was attended by scientists who have made a significant contribution to the paradigm shift as Giuseppe R.Brera, author of the theory of Person-centered Medicine and its teaching, taught to doctors at the Medical School of Milan since 1998, and pioneers of interactionism in their respective research areas such as Robert Cloninger (Psychobiology) Moshe Szyf, (Epigenetics), Claudio Violato (Medical Education), Lee Sun Wong, (Sterling and Heyer’s theory of allostasis), Jean Georges Maestroni (psycho-neuro-endocrine-immmunology), Piermario Biava, (Epigenetic reprogramming), George Christodoulou (World Federation of Mental Health), Vincenzo Di Nicola, President of the World Association of Social Psychiatry and Roy Kallivayalil ( Person-centered and Social psychiatry), Philippe Ney (Bioethics of life)Richard Fiordo (Health communication).

The conferences highlighted the urgent need to adapt to the current paradigm of Person-Centered Medicine, interactionist and teleonomic, the training of the doctor, public health policy and research. The basic sciences and the humanities, in fact, have allowed to reformulate in a personalistic sense the concept of human nature and health that appears to be the result of existential choices, which arises from the interpretative sense of the possibilities of experience that determine the quality of life. In fact, 95% of diseases are 95% lifestyle dependent and the remaining 5% on genetic dominance. Health, when it is not a biological emergency or a genetic disease, as documented by Professor Brera, who presented the theory, is consequently related to the symbolic work of interpretation of possibilities that interacts with biological variables, through the allostasis-revolution of physiology still unknown to most-theory of Peter Sterling and Joe Heyer- through the immunological and epigenetic psycho-neuro-endocrine modulation that allows adaptation to the change required in relationships with themselves, the human and physical environment. If truth for one’s own well-being and that of others and positive affections are the interpretative code of possibilities, health benefits. The great epistemological revolution of the indeterminist Person-Centered Medicine which has buried the mechanistic, determinist positivism, comparable only to the quantum revolution of physics, is given by the evidence of the multidimensional and multi-factorial origin of diseases that draws freedom and responsibility to the individual for quality of life, first of all of a spiritual nature, as founded on the truth or falseness of the meaning given to experience. This discrimination is the mother of moral thought-which is also the purpose of scientific research and philosophy. Medicine thus appears reformulated as a “Maieutic semiology of the person ” in whom illness appears as an event of life, signifying the work of man towards a harmonious unity of spirit, mind, and body, reminiscent of Aristotelian philosophy and the epistemological model of traditional Chinese medicine.

Illness appears a form of human nature whose substance hides therefore the unconscious or conscious teleonomic work of man and woman to realize themselves as a person, that is, the meaning of being men or woman, a concept absent in Aristotle, and in Chinese cosmology but of Christian derivation. The concept of health reformulated by MCP that dates back to 2011, already presented to WHO by Prof. Brera for its necessary adoption, must be redefined today in an interactionist and teleonomic sense as “Choosing the best possibilities to be the best human person”, also political program. The paradigm of Person-Centered Medicine, ethically based on Hippocratic values and irrefutably on the progress of the basic sciences and the humanities thanks to Kairology, should be the foundation of clinical medicine and the selection and training of physicians as an object of update in continuing education and the foundation of health policy. The second congress highlighted how the selection of students in medicine through cognitive tests, does not meet the requirements today required by the clinical method, especially the doctor’s empathy and the ability of “Diagnosis of the person”. They should be replaced by multi-dimensional assessments of attitudes as Prof.Brera has proposed. Unfortunately today medical and continuing education is still linked, except since 1999 in the Medical School of Milan of thAmbrosiana University, to the fragmentary separation in the clinical method between biology, quality of life, in the relationship with the physical, family, and work environment. Fragmentation dominates the research in the pathogenesis of clinical pictures, and medical education, with the omission of variables.

 This only bio-technological orientation, which does not correspond to current knowledge, causes serious damage to the health of the population and distances the person from a sense of responsibility for the quality of life, which arises from the meaning given to experience. This approach is particularly dramatic in a negative sense with adolescents, closed by dualism medicine and psychology, naturally led to answer the great questions of existence: love, truth, and beauty. This is why family doctors and pediatricians must train in person-centered medicine and medical counseling.

The goodness of the epistemological revolution has been confirmed by research that has documented how the training of doctors in Person-Centered Medicine leads to a huge saving in suffering and costs, for the decrease in prescriptions of drugs, specialist visits, and hospital admissions. Therefore the administrators of public health, have today the great moral responsibility to adapt the health system to Person-Centered Medicine, which directs to prevention and health education, for the good of the population. Its omission, born from ignorance, was responsible for the worldwide slaughter by COVID-19 for the absence of primary prevention strengthening natural immunity and early care. The removal of family members from hospitalized patients is one of the inhuman consequences of the pandemic of ignorance among doctors.

The problem appears dramatic because Medicine is developing in a schizophrenic way by dissociating between basic sciences that have documented interactionism and refuted Cannon (homeostasis) and Selye (mechanistic theory of stress) and the humanities that introduced the teleonomy of human nature and together changed the concept of human nature and health.

Instead, the orientation of Medicine is increasingly bio-technological, only valid if it remains an instrument and not a meaning in which the person becomes an object of techniques and profit. The sense of Medicine and the interpersonal dimension of the doctor. patient clinical relationships are irreplaceable.

The proceedings of the Congress are available without charge to the editorial department of Ambrosiana University: dipedit@unambro.it

We inform of the Summer Course in Person-Centered Medicine and Clinical Method centered on the person, addressed to doctors and teachers to be held from 4-9 September 2023 in Viareggio Ex-students, teachers of the Ambrosiana University, WASP and PCMIC members enjoy a 50% reduction on the registration fee. Participation in the course is valid for the updating of diplomas. Detailed information on www. scuolamedicamilano.it

 

Request for proceedings free of charge

to the Editorial Department  of Università Ambrosiana

dioedit@unambro.it 

JMazethes  Managing Editor

Copyright Università Ambrosiana 2023

PERSON-CENTERED MEDICINE : THE PARADIGM CHANGE IN MEDICAL SCIENCE AND MEDICAL EDUCATION  

 

 

Two significant world Congresses  promoted by Ambrosiana University on Person-Centered Medicine under the Patronage of

Pontifical Academy of Science

World Health Committee

European Parliament *

PERSON-CENTERED MEDICINE : THE PARADIGM CHANGE IN MEDICAL SCIENCE AND MEDICAL EDUCATION  

 under the patronage of the Pontifical Academy of Science, at the Pontifical Academy of Science
 (Holy Seat-Vatican State) on June 24 2023.
 
The Conference is particularly dedicated to deans of Medical School and to the world leaders in Medical Education and International health and physicians’ organizations 

The participation in the Conference  is possible only with institutional accreditation.

We also inform that the world Congress  in streaming (open to all investigators and clinicians also as individuals) has been postponed to 21-22-23 June

THE PARADIGM CHANGE OF MEDICINE: THE EPISTEMOLOGICAL AND SCIENTIFIC BASIS OF PERSON-CENTERED MEDICINE  

Keynote speakers:

Giuseppe R.Brera,Robert Cloninger,George Christodoulou,Roy Kallivayalil, George Maestroni, Philipe Ney,  Moshe Szyf, Claudio Violato, Lee Sun Won

Info about both the Congresses are on the University websites: www.unambro.it and www.healthparadigmchange.it (registration and abstract forms)

Registrations  ; secretariat@healthparadigmchange.it

                               segrgen@unambro.it

Ist COURSE OF PERSON-CENTERED PREVENTION AND TREATMENT OF COVID 19

The Medical School of Milan of the Ambrosiana University, with the Patronage of the Italian National Health Committee, organized the   specialization course,  dedicated to family and public health physicians  on the theme:

“Prevention and person-centered treatment of COVID-19 by variants of SARS-COV 2 and communicable diseases”

The course is the first edition in Italian of a European and international teaching program on the prevention of COVID-19, inspired by the Person-Centered Medicine application in theory and Medical Education, of which the Medical School of Milan of the Ambrosiana University is a pioneer and recognized world leader by the WHO. The course is aimed at teaching the correct epistemological and scientific paradigm to cope with the SARS-VOC 2 pandemic, based on the new antiviral allostasis and preventive immunostimulation paradigm, before a mass vaccination with genotoxic mRNA and vectorial vaccines also administered to children, adolescents and young people, not at risk of serious infections, if healthy. These mRNA and vector vaccines, inducers of an epigenetic earthquake, would have required years of experimentation to study even fatal adverse effects with serious damage to the health of the world population. The Course is coordinated by prof. Giuseppe R.Brera, currently the world’s leading expert on the prevention of COVID-19- wrote the only existing treatise on the subject and is the author of the theoretical paradigm of Person-Centered Medicine- is given by Maria Rita Gismondo, (Milan State University) virologist of international fame, Maurizio Federico, ( Director in the Italian Health Institute of the World Center of Global Health) who has in testing a pan-vaccine against the COVID-19, Salvatore Chirumbolo (University of Verona)  and Sergio Pandolfi  (University of Pavia) the most important Italian scholars on the early therapy of COVID-19, and the clinical “heresy” of the former Italian Health Minister’s, Roberto Speranza, illiterate paradigm” Paracetamol and vigilant wait” that cost thousands of deaths and hospital admissions. Medical Education is coordinated by prof. Vito Galante of the Milan School of Medicine with the quality procedure of the Ambrosiana University.

PROGRAM (1st edition-Italian)

Information to subscribe the European and International edition

communication@scuolamedicamilano.it

 

J Mazetes -Managing editor

The success of a pleiotropic integrated therapy against COVID-19

The success of a translational integrated therapy against COVID-19

Reading time: 9″

10.13140/RG.2.2.15071.12964/1

Giuseppe R.Brera*

A sixty years old unvaccinated woman, a great smoker, with a determinate temperament and basic trust, and a previous history of breast cancer with a swab positive diagnosis of COVID-19 developed a
temperature of 40 degrees, with headache and cough, an indicator of a high cytokine storm. She received an integrated therapy based on translational medicine structured on well-studied natural pleiotropic molecules
integrated with Nimesulide and Doxiciclin. The woman recovered from the severe COVID-19 syndrome in four days and joined the swab negativity in 10 days from the beginning of symptoms returning to work on the 11th day.

Article

  • Milan School of Medicine-Università Ambrosiana- Milano

 

Mass vaccination, the first time used to prevent a pandemic but with experimental mRNA and vectorial vaccines dangerous at the epigenetic-genetic level,[1] [2] [3] [4] and offered to the market with unreliable clinical research methods [5] [6] , and producing high rates of adverse effects and mortality, met in a minority of people also physicians and investigators a right diffidence and prudency to vaccinate people and themselves. These sera should have requested larger samples and a long time to be studied. The basic epistemological error caused by the lack of adoption in public health of the paradigm change of medical science and medicine, Person-Centered Medicine, must find an effective and cheap alternative allowing people primarily in countries with poor financial resources to prevent and care for viral and bacterial infections. To date, the deterministic-mechanistic paradigm used to cope with the pandemic implementing only biotechnology and profit is “Pathogen= mortality risk! and not the right indeterministic multidimensional one:” Pathogen-anti-pathogen allostasis = immunity-resilience- recovery”.[7] According to the Person-centered medicine primary prevention and therapy paradigm,clinical efforts must be addressed to improve life quality and psycho-biological resources to prevent and care for diseases and not to be problem-centered which improves only the disease-centered stock market. The World Health Charter should be adopted worldwide.

Anti-viral drugs and monoclonal antibodies are developed through fragmented research methods and show dangerous adverse effects while there are in nature pleiotropic, powerful and cheap molecules that, without adverse effects act contemporary at a biochemical and immunological level showing a great preventive action and efficacy and therapy. This is the road map for prevention and therapy based on the physiology revolution of “allostasis” (Sterling and Heyer) [8] substituting the obsolete concept of “Homeostasis”(Cannon) taught yet and unknown to most clinicians and investigators.

The anti-viral targets of prevention and a successful therapy anti-SARS-COV 2 variants of concern (VOC) must be addressed at the same time to prevent the virus binding to receptors, (barrier effect) inhibition of proteases, prevention of NK and CD8inactivation by viruses, re-activation of the P53 gene, preventing the critical anergy after the seventh day of the disease shared by patients with atherosclerosis -based comorbidities, reinforcement of natural humoral immunity, and prevention of the virus-induced viral allostatic metabolism and generation of anti-viral allostasis, prevention of cytokine storm-induced lung inflammation and antiviral allostasis in oral, nasal mucosae and upper respiratory ways, and an antiviral allostasis metabolism generation.

One of us recently introduced to the COVID prevention and early treatment of the epistemological concept of anti-viral allostasis and immunostimulation identifying the relativity of the SARS-COV 2 entry into cells and reviewing the anti-viral targets of naturals molecules spread worldwide [9] [10]  according to the Person-centered prevention strategy” inspired by Person-Centered Medicine, the current paradigm of Medical Science, [11] [12]  which at the clinical level introduced the Person-Centered Clinical Method that allows the physician the identification of the subjective-biological-environmental patient’s resources addressed to improve the person and lifestyle, [13]   not reducing the clinical case to be a probabilistic event of a natural law variation, [14] but concerning the relation with the person’s subjective being, comprising in existence and resulting in life quality related to the spiritual- psycho-neuro-endocrine, immunity  [15], and epigenetic individual system.

The COVID-19 prevention and early treatment inducing an anti-viral allostasis (AVAL) and immunostimulation (IMUST) is entrusted to the person’s natural immune system and can be reinforced by a resource-centered healthy lifestyle and powerful anti-viral substances with act as natural epigenetic programmers at immunity -biochemical level. Nutrition quality is part of a healthy or bad life quality. Curcumin, Aloe, Lactoferrin, Epigallocatechin, Beta-glucans Sphingosine, Mannan binding lectins, and Quercetin are natural molecules with a well-documented powerful pleiotropic antiviral allostasis and immunostimulant actions  [16] [17] . Vit A and C are immunostimulants and VIT D metabolite, [18] cathelicidin has direct virucide properties. Nimesulide has stronger anti-inflammatory and antiviral properties, with well-studied significant therapeutic successes,[19] and its association with maltodextrins results also in immunostimulation. [20] [21]  Doxiciclin has also antibacterial and antiviral properties. [22] Conversely the antipyretic tachipirine, suggested by the Italian Health Ministry to treat early COVID is dangerous because it promotes coagulation and has not ant-inflammatory effects. [23]

A sixty years old unvaccinated woman, a great smoker, with a determinate temperament and good basic trust, and a previous history of breast cancer with a swab positive diagnosis of COVID-19 developed a temperature of 40 degrees, with headache and cough, an indicator of a high cytokine storm. Tachipirin administration, prescribed by phone by an emergency unit according to the Italian health ministry indications was suspended and a translational therapy integrated with drugs was prescribed with the resolution of COVID-19 syndrome in four days and negativity of swab in 10 days. The woman started to work on the 11th day. Posology is indicated in table 1 (Table 1)

Genotoxic and immunosuppressive mRNA and vectorial vaccines, silencing microRNA and/or hybridizing DNA [24]  produce only circulating IGG, waning in a short time and are inactive against VOC not induce protective mucosal IGA and do not generate Memory B Cell in lungs [25]  with a high rate of life-threatening adverse effects. Cells’ methylation induces an increased risk of cancer. [26]     Monoclonal antibodies and anti-viral drugs have many adverse effects and are expensive, while translational medicine and its integration significant could promote effective prevention and therapy worldwide at low cost with high availability of natural anti-viral molecules. Moreover, there is the impossibility to vaccinate the entire world, and integrated therapy could offer cheap possibilities to all for self-care through health education. Person-centered translational prevention and therapy based on preventive antiviral allostasis and immuno-stimulation and self-care in poor countries all over the world, by correcting the epistemological error determining the failure of the pandemic prevention  is a new perspective for public health to prevent communicable and non-communicable diseases worldwide, without submitting people to experimental mass vaccines.

 

[1]    Lockhart J, Canfield J, Mong EF, Vanwye J, Totary-Jain H. Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019;14:339-350. doi:10.1016/j.omtn.2018.12.00

[2]   Doerfler W. Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. doi: 10.1016/j.virusres.2021.198466. Epub 2021 Jun 1. PMID: 34087261; PMCID: PMC8168329.

[3]    Seneff, S., Nigh, G., Kyriakopoulos, A. M., & McCullough, P. A. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Food and chemical toxicology 2022; 164, 113008. Internet:https://doi.org/10.1016/j.fct.2022.113008

[4]    Brera G.R. Scientific evidence of mRNA and vectorial vaccines genotoxicity inducing tumors and psycho-neuro-behavioral disorders. Scientific Report of the Milan School of Medicine; December 7 2021 DOI: 10.13140/RG.2.2.29151.18081

[5]    Cotton C. Lecture méthodologique desrésultats des essais cliniques des vaccins COVID-19. Internet   https://www.francesoir.fr/sites/francesoir/files/media-icons/Revue-des-Essais-Cliniques-COVID-Christine-Cotton.pdf

[6]    Cotton C. Evaluation des pratiques méthodologiques mises en œuvre dans les essais Pfizer dans le développement de son vaccin ARN-messager contre la COVID-19 en regard des Bonnes Pratiques Cliniques Présentation OPECTS Christine COTTON 1 A Maxime Beltra Christine COTTON – 05/04/2022 – © L

[7]     Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432

[8]    Sterling P.,Eyer J. Allostasis: a new paradigm to explain arousal pathology. In: Fischer S Reason J. editors. Handbook of Life Sciences, cognition, and Hea[7] Robinson E.G., Fernald R., Clayton D. Genes and Social Behavior.Science 2008;322:896-lth. New York 1988: J.Wiley and sons;p. 629-649

[9]    Brera G.R. SARS-COV 2 allostasis and the people and person-centered prevention. A new prevention strategy based on people’s metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Università Ambrosiana , 2021. ISBN: 9798530093906

[10]    Brera G.R . SARS-COV 2- allostasis and the people   and person-centered prevention.  Part 2 The Sars-Cov 2- induced immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation -How to induce zero risk for covid-19. Milan:  Ambrosiana University: 2021. ISBN: 9798547583520

[11]   7

[12]   Brera G. R, The manifesto of Person-Centred Medicine. Medicine, Mind and Adolescence 1999.XIV, 1-2:7-11

[13]  Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432

[14] Gadamer H-G Where health is hidden. Frankfurt; Suhrkamp Verlag, 1993 (German)

[15]  Lissoni P The spirit marries the science. Calco, Ripamonti tip, 2008 (Italian)

[16] 8-9

[17]  Qingqing Dai, Yasumasa Morita, Yongbo Huang, et al) Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles. Journal of Inflammation Research. 2019; 12: 335-343

[18]  Mitra S, Paul S, Roy S, Sutradhar H, Bin Emran T, Nainu F, Khandaker MU, Almalki M, Wilairatana P, Mubarak MS. Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review. Molecules. 2022 Jan 16;27(2):555. DOI: 10.3390/molecules27020555. PMID: 35056870; PMCID: PMC8779769.

[19]  Suter F, Consolaro E, Pedroni S, et al. A simple, home-therapy algorithm to prevent hospitalization for COVID-19 patients: A retrospective observational matched-cohort study. clinical medicine. 2021 Jul;37:100941. DOI: 10.1016/j.eclinm.2021.100941. Epub 2021 Jun 9. PMID: 34127959; PMCID: PMC8189543. (Medrix 25/03/2021

[20]  Gozzi-Silva SC, Teixeira FME, Duarte AJDS, Sato MN, Oliveira LM. Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve? Front Nutr. 2021 Sep 7;8:674258. doi: 10.3389/fnut.2021.674258. PMID: 34557509; PMCID: PMC8453008.

[21]   Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc. 2005;2(5):403-11.  DOI: 10.1513/pats.200508-090JS. PMID: 16322590; PMCID: PMC2713330.

[22]  Dorobisz K, Dorobisz T, Janczak D, Zatoński T. Doxycycline in the Coronavirus Disease 2019 Therapy. Ther Clin Risk Manag. 2021 Sep 21;17:1023-1026. doi: 10.2147/TCRM.S314923. PMID: 34584416; PMCID: PMC8464303.

[23]  Pandolfi S, Simonetti V, Ricevuti G, Chirumbolo S. Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients? J Med Virol. 2021 Oct;93(10):5704-5706. doi: 10.1002/jmv.27158. Epub 2021 Jun 30. Erratum in: J Med Virol. 2022 Mar;94(3):1246. PMID: 34170556; PMCID: PMC8426871.

[24]   1-2-3-4

[25]  Federico M. Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody Production. Journal of Immunology Research. 2022. DOI  https://doi.org/10.1155/2022/4028577

[26]  Huang L, Liang D, Zhang Y, et al. METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b. J Cancer Res Clin Oncol. 2022 Nov 8. doi: 10.1007/s00432-022-04429-9. Epub ahead of print. PMID: 36348020.

 

 

 

 

 

 

 

 

 

Table 1

 

 Substance-molecule   Posology
   Curcumin Curcumin 500 mg x2

5’Inhalation of turmeric powder (10 g- two tea spoons) vapors  from a solution with 100 ml of water at boiled temperature
Aloe extract  50 ml x 2
Lactoferrin 200 mg x 2 before meals
Epigallocathechin  Infusion of green tea (40°) four glasses per  day ( 800 ml )
Resveratrol 1000 mg x 2 before meals
Sphingosine and Beta-glucans Kefir milk 200 ml x 3
Melatonin 5 mg ( evening
Vit D10 10.000 U ( 7 days) after  1000
Vit, C 500 mg
Vit A 1000 U
Nimesulide and maltodextrins 400 mg x 2
Doxiciclin 200 mg a day
Table 1  Posology of the integrated therapy-

( Doses are referred one-two times a day ,morning and evening)

 

 

Radiation Emitted by Wireless Devices and Male Reproductive Hormones

 2021; 12: 732420.
Published online 2021 Sep 24. doi: 10.3389/fphys.2021.732420
PMCID: PMC8497974
PMID: 34630149

Effect of Radiation Emitted by Wireless Devices on Male Reproductive Hormones: A Systematic Review

Sofwatul Mokhtarah Maluin, 1 , 2 Khairul Osman, 3 Farah Hanan Fathihah Jaffar, 1 and Siti Fatimah Ibrahim 1 , *
Author information Article notes Copyright and License information Disclaimer

Exposure to radiofrequency electromagnetic radiation (RF-EMR) from various wireless devices has increased dramatically with the advancement of technology. One of the most vulnerable organs to the RF-EMR is the testes. This is due to the fact that testicular tissues are more susceptible to oxidative stress due to a high rate of cell division and mitochondrial oxygen consumption. As a result of extensive cell proliferation, replication errors occur, resulting in DNA fragmentation in the sperm. While high oxygen consumption increases the level of oxidative phosphorylation by-products (free radicals) in the mitochondria. Furthermore, due to its inability to effectively dissipate excess heat, testes are also susceptible to thermal effects from RF-EMR exposure. As a result, people are concerned about its impact on male reproductive function. The aim of this article was to conduct a review of literature on the effects of RF-EMR emitted by wireless devices on male reproductive hormones in experimental animals and humans. According to the findings of the studies, RF-EMR emitted by mobile phones and Wi-Fi devices can cause testosterone reduction. However, the effect on gonadotrophic hormones (follicle-stimulating hormone and luteinizing hormone) is inconclusive. These findings were influenced by several factors, which can influence energy absorption and the biological effect of RF-EMR. The effect of RF-EMR in the majority of animal and human studies appeared to be related to the duration of mobile phone use. Thus, limiting the use of wireless devices is recommended.

Keywords: mobile phone, Wi-Fi, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH)

ARTICLE

Long-term exposure to electromagnetic radiation decreases estrogens and prolactin

Long-term exposure to electromagnetic radiation from mobile phones and Wi-Fi devices decreases plasma prolactin, progesterone, and estrogen levels but increases uterine oxidative stress in pregnant rats and their offspring

Murat Yüksel 1, Mustafa Nazıroğlu 2, Mehmet Okan Özkaya 1
Affiliations 

Abstract

We investigated the effects of mobile phone (900 and 1800 MHz)- and Wi-Fi (2450 MHz)-induced electromagnetic radiation (EMR) exposure on uterine oxidative stress and plasma hormone levels in pregnant rats and their offspring. Thirty-two rats and their forty newborn offspring were divided into the following four groups according to the type of EMR exposure they were subjected to: the control, 900, 1800, and 2450 MHz groups. Each experimental group was exposed to EMR for 60 min/day during the pregnancy and growth periods. The pregnant rats were allowed to stand for four generations (total 52 weeks) before, plasma and uterine samples were obtained. During the 4th, 5th, and 6th weeks of the experiment, plasma and uterine samples were also obtained from the developing rats. Although uterine lipid peroxidation increased in the EMR groups, uterine glutathione peroxidase activity (4th and 5th weeks) and plasma prolactin levels (6th week) in developing rats decreased in these groups. In the maternal rats, the plasma prolactin, estrogen, and progesterone levels decreased in the EMR groups, while the plasma total oxidant status, and body temperatures increased. There were no changes in the levels of reduced glutathione, total antioxidants, or vitamins A, C, and E in the uterine and plasma samples of maternal rats. In conclusion, although EMR exposure decreased the prolactin, estrogen, and progesterone levels in the plasma of maternal rats and their offspring, EMR-induced oxidative stress in the uteri of maternal rats increased during the development of offspring. Mobile phone- and Wi-Fi-induced EMR may be one cause of increased oxidative uterine injury in growing rats and decreased hormone levels in maternal rats.

Graphical abstract: TRPV1 cation channels are the possible molecular pathways responsible for changes in the hormone, oxidative stress, and body temperature levels in the uterus of maternal rats following a year-long exposure to electromagnetic radiation exposure from mobile phones and Wi-Fi devices. It is likely that TRPV1-mediated Ca(2+) entry in the uterus of pregnant rats involves accumulation of oxidative stress and opening of mitochondrial membrane pores that consequently leads to mitochondrial dysfunction, substantial swelling of the mitochondria with rupture of the outer membrane and release of oxidants such as superoxide (O2 (-)) and hydrogen peroxide (H2O2). The superoxide radical is converted to H2O2 by superoxide dismutase (SOD) enzyme. Glutathione peroxidase (GSH-Px) is an important antioxidant enzyme for removing lipid hydroperoxides and hydrogen peroxide and it catalyzes the reduction of H2O2 to water.

A RESEARCH MANIFESTO FOR THE WITHDRAWL OF ANTI-COVID 19 mRNA AND VECTORIAL VACCINES

The COVID-19 pandemic finds its basis in the epistemological error imperant in medicine and public health: To date, the obsolete and wrong deterministic-mechanistic paradigm used to cope with the pandemic implementing only biotechnology and profit is “Pathogen-infection- mortality risk” and not the right indeterministic multidimensional one:” Pathogen-anti-pathogen allostasis = antiviral metabolic allostasis and immunity stimulation -resilience- recovery.” the basis of Person-Centered Medicine that states that health is: ” The choice of the best possibilities for being the best human person.” Truth, freedom, and health are inseparable.

( Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432)

The error led to the omission of secondary prevention, which should have been based on research on the first 2002 SARS-COV and 2009 MERS disappeared without mass vaccination.

The error leads to the omission of secondary prevention in the oldest people at risk with comorbidities (93% of deaths).

Genotoxicity due to the silencing of mi-RNA to promoter genes by mRNA vaccines but to date has not yet been investigated in their epidemiological consequences. There is evidence of risk of mortality, cardiovascular and oncological morbidity after vaccination, and a high-risk index for adverse effects, including increased vulnerability to cancer, autoimmune diseases, and cardiovascular diseases. These data call for the immediate withdrawal of mRNA sera worldwide.

Immunodepression induced by multiple injections of mRNA vaccines has been demonstrated. In fact, after two doses, the unvaccinated are more protected from infection than the unvaccinated.

( Lancet: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2822%2900089-7).

Moreover, there are no” large differences in the median duration of viral shedding among participants who were unvaccinated, those who were vaccinated but not boosted, and those who were vaccinated and boosted.” Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron…

These observations, along with the AB mRNA vaccines waning and the lack or weak presence of IGA in mucosae of upper respiratory ways, make the persecution made by some countries against prudent unvaccinated health professionals a delusion of illiterate governments that prescribed an obligement to vaccination.

Vectorial sera have a great probability of hybridizing human DNA and present risk of autoimmunity and induced cardiovascular pathologies up to death like mRNA.

There are other forms of prevention and easy treatment of COVID-19 in the early stages that make them useless. The state of Florida (USA), having found a risk of 2.3 for mortality in subjects vaccinated by mRNA sera with an 83% increase in mortality under 39 years, has prohibited them. Swede, Denmark, and Canada, respectively. didn’t recommend vaccination under 19-50-60 yo. The induction of children and young people’s vaccination is a crime against humanity motivated only by profit and power, as the Nobel prize Luc Montagnier agreed.

The 2002 SARS-VOC epidemics and the 2010 MERS have disappeared without mass vaccinations in a year. Mass vaccinations, in addition, in times of epidemic, select increasingly dangerous variants for the evasion of the immune system, an enormous business for BIG PHARMA.

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This letter is intended to propose to Research Gate researchers a World Manifesto for the withdrawal of mRNA vaccines from the market as follows.:

“Researchers of the Research Gate, by highlighting the danger of mass vaccination and boosting with mRNA and vectorial sera for the world health people, make an appeal to governments for their withdrawal from the market and the withdrawal by governments of vaccination obligations. RG researchers, moreover, make an appeal to suspend any crazy suspension from the work of unvaccinated health professionals because of the lack of any scientific motivation and the result of governments’ illiteracy which led to a violation of human rights.”

Adherence to the World Manifesto takes place through adherence to this initiative in the discussion and mail to

researchgatemanifesto@worldhealthcommittee.net

, subscribing to the site and supporting this initiative if you agree.

Attend to the discussion on www.researchgate.net

Giuseppe R. Brera

President of the World Health Committee

www.worldhealthcommittee.net

President of the Italian National Health Committee

www.comitatosanitarionazionale.it

Director of the Milan School of Medicine

www.scuolamedicamilano.it

 

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