PERSON-CENTERED PREVENTION, RISKS FORM GENETIC VACCINES,EARLY THERAPY FROM COVID-19

nder the Patronage of the World Health Committee

and “ Comitato Sanitario Nazionale” (Italy)

 “  PERSON-CENTERED MEDICINE, PREVENTION  AND ADOLESCENCE

3rd session : 20 Novembre 2021 - h 15-  Zoom

PERSON-CENTERED PREVENTION, RISKS FORM GENETIC VACCINES,EARLY THERAPY FROM COVID-19

Introduction to the third session and welcome

Giuseppe R.Brera

Rector of the Ambrosiana University

PROGRAM

Chair

Prof. Vito.Galante MD  PH D LD MA

Honorary Chair in Adolescentology  at the Ambrosiana University 

Scientific Secretary of the Congress               

15,15-15,40+5’

Keynote lecture

“The Experimental Child”

Mental and Social Consequences for Children and Families  of the Coronavirus Syndemic      *

Vincenzo Di Nicola, MPhil, MD, Ph.D., FRCPC, DFAPA, FCPA, FCAHS

Honorary Chair (Licentia Docendi, LD) & Professor (Magister, MA Sc),  Ambrosiana University

Professor of Psychiatry, University of Montreal

Clinical Professor of Psychiatry, The George Washington University

15,45-16,10+5 

Keynote lecture

Effects of current anti-SARS-COV 2 vaccines beyond anti‐Spike antibody generation

Maurizio Federico

Director

National Center for Global Health

Istituto Superiore di Sanità (Italy) 

       Keynote lecture

  16,10-16,35+5

Scientific evidence of epigenetic and genetic damages from anti-SARS-COV 2 vaccines and the epidemiologic confirmation of risks from vaccination.The need for the person-centered prevention paradigm inducing the “Antiviral allostasis and the preventive immunostimulation.

Giuseppe R.Brera MD, MA, MA LD

Director of the Milan School of Medicine, President of the World Health Committee 

and Italian National Health Committee

16,35-17+5’

Discussion and free contributions (max7’)   

                                                           (In Italian and English)

17,15-18,45

1^st  Workshop

of the

   WORLD HEALTH COMMITTEE

Chair

Roy Kallivayalil

Secretary-General of the World Health Committee

Introduction

Giuseppe R.Brera

President of the World Health Committee

Contribution of  the  WHC Scientific Committee’s members 

17,30-18,20

Robert Cloninger, Claudio Violato, Richard Fiordo, George Christodoulou, Roy Kallivayalil, Giuseppe R.Brera

18,20-18,45-

Contributions of invited speakers

18,45

End of the Conference

Giuseppe R.Brera

Rector of the Ambrosiana          

          SUMMARY OF THE THIRD SESSION's  PROCEEDINGS

    The recent international conference :[1] in the third session dedicated to "Person-centered prevention, risks from genetic vaccines, early therapy of Covis-19" highlighted

The "pandemic" must be renamed "Syndemic" because of theeffects on the      mental health of children and adolescents. We  face the phenomenon of the "Experimental child." ( V. Di Nicola)

that infection with SARS-COV 2 and variants is dangerous only with comorbidity and affects 92% of people at risk. The increased risk of severity of COVID-19 is proportional to the increased comorbidity factors; (Antos A, Kwong ML, Balmorez et al- cit. Brera)[2

that there is an increased risk of mortality in vaccinated older people, compared to non-vaccinated people with a seconddose before six months from the first; there is a tendency to an increase in risk in subjects between 12-39 years, and after the first dose in subjects 60-79;[3](from ISS raw data)[4]  (Brera-Violato) TAB 2

that children, healthy adolescents, and young people up to 29 years of age are virologically not at risk of systemic cellular infection ( entry of the virus into all cells of the organism) due to the healthy conformation of cell membranes that prevent the entry of the virus into cells for the absence of "Lipid rafts" and are not "Untori" [5][6] [7][8] [9], indeed valuable artifacts of herd immunity. The rare and asymptomatic cases appear to be due only to virus-monocyte circulating plasmacytoid interaction and humoral immune reaction. The children and adolescents' humoral immunity power is confirmed by the fatality/case ratio 0 (Tab-1), while severe adverse effects after vaccination are frequent (9,3%) (Brera, Molteni, Byambasuren, Madewell, cit. Brera). Vaccination[10] resulted in deaths in healthy adolescents who would be alive if media would not orchestrate a campaign to induce them to vaccination;  (TAB 1)

 that mRNA vaccines[11]are genotoxic, ([12] [13] [14]) because the substitution of an RNA base, the uridine with the pseudouridine, carried out in the production in order to avoid the natural immunity of the injected organism and the increase in the speed of the translation. The biochemical link induced by N1-methyl pseudouridine with micro-RNAs, causes their alteration and silencing, making the inoculated organism more vulnerable to solid tumors and leukemia, changes in the nervous system mental retardation, learning disorders, Asperger syndrome;  (Lockhart-Schratt-Raish-Zeng cit. Brera)

 cell methylation, induced by N1-methyl-pseudouridine at both epigenetic and genetic (DNA) levels, produces an additional risk factor for cancer vulnerability;[15][16](Li, Zeng cit.Brera

 that mRNA vaccines neither induce the synthesis of antiviral immunocytes (CD8 +) nor produce a memory of them;[17](Federico

that mRNA vaccines do not affect the transmissibility of the virus and its variants because they do not induce the defense of IGA (antibodies to prevent the entry of the virus into the oral and[18]nasal mucous membranes; (Federico) therefore taking away any scientific validity to the establishment of the "Green Pass" as vaccinated and unvaccinated have the same probability of transmitting the virus

 that the mRNA vaccines do not interact with other than the B cells of memory resident in the lungs, which are responsible for protecting against lung infections; [19](Allie cit. Federico), making vaccines not influential on infections of lungs by SARS-COV 2;

11.that SARS-COV 2 virus by nature and by vaccination induction is selecting     increasingly dangerous and immuno-resistant variants;[20] (Federico-Garcia);

 12. that the reduction in immunity induced by mRNA vaccines is constant until it drops to 16.1% of subjects below the 50% threshold after six months against 10.8% of those cured after nine months[21]of infection. . After six months, the level of IGG drops in vaccinated by 40% each month against less than 5% of convalescents (Israel-Federico);

13.that adenoviruses of vector vaccines hybridize with human DNA ( Astra-Zeneca-adenovirusof chimpanzee).[22]Furthermore, they increase[23] vulnerability to autoimmune diseases and tumors (experimental certainty). By activating the immune response of the organism against adenovirus- about 50% of the population is immunized- mRNA is destroyed and therefore do not produce immunity against Spike proteins, canceling their antigenicity and in children and adolescents can induce an immuno-complex disease and fatal thrombotic reactions, as already occurred in a teenager in Genoa (Doerfler cit.Brera).

Conclusion

                   Anti-COVID 19 genetic vaccines to date administrated to populations induce severe risks for people's health, primarily for children and adolescents not at risk of a rare severe clinical syndrome if healthy. In this age range, the objective COVID-19 possible severity is prevented by innate humoral immunity that does not allow the virus entering in cells and create the asymptomatic condition necessary for the induction of herd immunity.

    COVID-19 can readily be prevented by inducing a metabolic –immune shield for people through health education, primary care, and self-care called:"Antiviral allostasis and preventive immunostimulation.  It induces a healthy lifestyle, significantly preventing other communicable diseases and canceR.

   There is the urgent need for a change of the WHO, world and European strategy to prevent SARS_COV 2 variants risks for people health that paradoxically this kind of genetic vaccines favor because more inoculations correspond to the establishment and a proportional increase of immunodepression and exposition to cancer and neurobiological and behavioral diseases and disorders through the micro-RNA silencing.

[1] Università Ambrosiana. Medical Science and Health Paradigm Change. G.R. Brera ed: Proceedings from the Conference: Medical Science and Health Paradigm Change. Milan 13-14-15 October 2017. Internet: www.healthparadigmchange.it

[2] Antos A, Kwong ML, Balmorez T, Villanueva A, Murakami S. Unusually High Risks of COVID-19 Mortality with Age-Related Comorbidities: An Adjusted Meta-Analysis Method to Improve the Risk Assessment of Mortality Using the Comorbid Mortality Data. Infect Dis Rep. 2021;13(3):700-711. Published 2021 August 8. doi:10.3390/idr13030065

[3] Brera G.R, Violato C Significant mortality increase in >80 anti-Sars-COV 2 vaccinated people compared to unvaccinated, a tendency in 12-39 people and the anti-covid 19 vaccines genotoxicity. Scienific Reports of the Ambosiana University Scuola Medica di Milano-Milan School of Medicine. November 16, 2021

[4] Italian health Institute-Epicentro Pandemic COVID-19 Updating August 18, 2021 Internet https://www.epicentro.iss.it/coronavirus/bulletin/Bollettino-surveillance-integration-COVID-19_18agosto2021.pdf

[5] Brera G.R Sars-Cov-2 allostasis and the people and person-centered prevention. A new prevention strategy based on a people metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Università Ambrosiana , 2021. ISBN: 9798530093906

[6] Brera G.R. SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The Sars-Cov 2- induced
Immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation How to induce zero risk for covid-19. Milan: Ambrosiana University: 2021 I ISBN: 9798547583520

[7] Erika Molteni, H. Sudre, Liane S. Canas, Sunil S. Bhopal, et al. Illness duration and symptom profile in a large cohort of symptomatic U.K. school-aged children tested for SARS-Cov-2. Lancet; 2021

internet file:///C:/Users/Utente/Documents/UA/ricerca/Corona%202/Illness%20duration%20and%20symptom%20profile%20in%20symptomatic%20UK%20school-aged%20children%20tested%20for%20SARS-CoV-2%20-%20The%20Lancet%20Child%20&%20Adolescent%20Health.html

[8] Byambasuren O.Cardona M.Bell K.et al. Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis. J Assoc Med Microbiol Infect Disease Canada (JAMMI). 2020; 4: 223-234

[9] Madewell ZJ, Yang Y, Longini IM, et al. Household Transmission of SARS-CoV-2. A systematic review and meta-analysis. JAMA Netw Open 2020;3(12):e2031756.doi: 10.1001/jamanetworkopen.2020.31756. 12.18.20

[10] From the USA Center of Disease Controls and Prevention: VAERS Data about adolescents' Deaths after vaccination: 9,3 % severe adverse effects from vaccination and 14 deaths

" CDC reviewed 14 reports of death after vaccination. Among the decedents, four were aged 12–15 years, and 10 were aged 16–17 years. All death reports were reviewed by CDC physicians; impressions regarding the cause of death were pulmonary embolism (two), suicide (two), intracranial hemorrhage (two), heart failure (one), hemophagocytic lymphohistiocytosis and disseminated Mycobacterium chelonae infection (one), and unknown or pending further records (six).

From CDC V-SAFe data:

" During December 14, 2020–July 16, 2021, v-safe enrolled 66,350 adolescents aged 16–17 years who received Pfizer-BioNTech vaccine (Table 3). After Pfizer-BioNTech vaccine was authorized for adolescents aged 12–15 years (beginning May 10, 2021), v-safe enrolled 62,709 adolescents in this age group. During the week after receipt of dose 1, local (63.9%) and systemic (48.9%) reactions were commonly reported by adolescents aged 12–15 years; systemic reactions were more common after dose 2 (63.4%) than dose 1 (48.9%). Reporting trends were similar for adolescents aged 16–17 years: systemic reactions were reported among 55.7% after dose 1 and 69.9% after dose 2. For each dose and age group, reactions were reported most frequently the day after vaccination. The most frequently reported reactions for both age groups after either dose were injection site pain, fatigue, headache, and myalgia.

Internet: https://www.cdc.gov/mmwr/volumes/70/wr/mm7031e1.htm

During the week after receiving dose 2, approximately one-third of adolescents in both age groups reported fever. Nearly one-quarter of adolescents in both age groups reported they were unable to perform normal daily activities the day after dose 2. Fewer than 1% of adolescents aged 12–17 years required medical care in the week after receipt of either dose; 56 adolescents (0.04%) were hospitalized

[11] Brera G.R. Scientific evidence of mRNA and vectorial vaccines genotoxicity inducingtumorsandpsycho-neuro- behavioral disorders.
Pre-print INTERNET https://zenodo.org/record/5763850#.YbNfCr3MLIW

[12]Lockhart J, Canfield J, Mong EF, Vanwye J, Rotary-Jain H. Nucleotide   Modification Alters MicroRNA-Dependent  Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019;14:339-350. doi:10.1016/j.omtn.2018.12.00


[13]  Schratt G. microRNAs at the synapse. Nat Rev Neurosci. 2009 Dec;10(12):842-9.   DOI: 10.1038/nrn2763. Epub 2009    November 4. PMID: 19888283.


[14]  Raisch J, Darfeuille-Michaud A, Nguyen HT. Role of microRNAs in the immune  system, inflammation and cancer.  World J Gastroenterol. 2013;19(20):2985-2996. doi:10.3748/wjg.v19.i20.2985


[15]   Li, T., Hu, PS., Zuo, Z. et al. METTL3 facilitates tumor progression via an m6A- IGF2BP2-dependent mechanism in  colorectal carcinoma. Mol Cancer 18, 112 (2019). https://doi.org/10.1186/s12943-019-1038-7


[16]  Zeng, C., Huang, W., Li, Y. et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol  13, 117 (2020). https://doi.org/10.1186/s13045-020-00951-w


[17] Federico M Biological and immune responses to current anti‐SARS‐ CoV‐2 mRNA vaccines beyond anti‐Spike antibody production. Proceedings 
of the Conference Person-Centered Medicine, prevention and adolescence; III° Session: Person-centered prevention, risks from genetic vaccines, early therapy of COVID-19; 2021 Nov.20 ; Milan, University Ambrosiana. 2021. p 44-45. 


[18]   Ibidem 17


[19]  Allie, S.R., Bradley, J.E., Mudunuru, U. et al. The establishment of resident memory    B cells in the lung requires local antigen encounter. Nat Immunol 20, 97–108 (2019). https://doi.org/10.1038/s41590-018-0260-6


[20]  Garcia-Beltran,Wilfredo F. et al  Multiple SARS-COV 2 variants escape    neutralization by vaccine-induced humoral     immunity. 2021; Cell, 184,9: 2372-2383


[21]  Israel A, Shenhar Y, Green I, et al. Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. Preprint. medRxiv. 2021;2021.08.19.21262111.

        Published 2021 August 21. doi:10.1101/2021.08.19.21262111

[22]  Federico M The conundrum of current anti-SARS-CoV-2 vaccines. Cytokine & Growth Factor Reviews.2021;60:45-61.


[23]   Doerfler W. Adenoviral Vector DNA- and SARS-Cov-2 mRNA-Based Covid-19 Vaccines: Possible Integration into   the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. DOI: 10.1016/j.virusres.2021.198466. Epub 2021 June 1. PMID: 34087261; PMCID: PMC8168329

TAB 1

AGE-RELATED ASSOCIATIONOF THE FATALITY/CASES RATE

TAB 2

FATALITY INCREASE IN VACCINATED OLDEST PEOPLE