Tag: COVID-19

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

 

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Peter I Parry 1 2, Astrid Lefringhausen 3, Conny Turni 4, Christopher J Neil 5, Robyn Cosford 3, Nicholas J Hudson 6, Julian Gillespie 3
Affiliations 

 

Abstract

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely

 

Key Points

  • Highly safe and effective vaccines are central to combat infectious disease epidemics/pandemics.
  • SARS-CoV-2 spike protein is pathogenic, whether from the virus or created from genetic code in mRNA and adenovectorDNA vaccines.
  • Biodistribution rodent study data show lipid nanoparticles carry mRNA to all organs and cross blood-brain and blood-placenta barriers. Some of these tissues are likely to be impervious to viral infection; therefore, the biohazard is particularly from vaccination.
  • Lipid-nanoparticles have inflammatory properties.
  • The modification of mRNA with N1-methylpseudouridine for increased stability leads to the production of spike proteins for months. It is uncertain how many cells and from which organs mRNA spike proteins are produced, and therefore, the exact effective dose delivered per vaccine vial is unknown.
  • The long-term fate of mRNA within cells is currently unknown.
  • The mRNA and adenovectorDNA vaccines act as ‘synthetic viruses’.
  • In the young and healthy, and even in many older individuals with vulnerable comorbidities, the encoding-based COVID-19 vaccines will likely transfect a far more diverse set of tissues than infection by the virus itself.
  • Evidence suggests reverse transcription of mRNA into a DNA copy is possible. This further suggests the possibility of intergenerational transmission if germline cells incorporate the DNA copy into the host genome.
  • Production of foreign proteins such as spike protein on cell surfaces can induce autoimmune responses and tissue damage. This has profoundly negative implications for any future mRNA-based drug or vaccine.
  • The spike protein exerts its pathophysiological effects (‘spikeopathy’) via several mechanisms that lead to inflammation, thrombogenesis, and endotheliitis-related tissue damage and prion-related dysregulation.
  • Interaction of the vaccine-encoded spike protein with ACE-2, P53 and BRCA1 suggests a wide range of possible biological interference with oncological potential.
  • Adverse event data from official pharmacovigilance databases, an FDA-Pfizer report obtained via FOI, show high rates and multiple organ systems affected: primarily neurological, cardiovascular, and reproductive.
  • Pfizer and Moderna mRNA COVID-19 vaccines’ clinical trial data independently interpreted has been peer-review and published to show an unfavourable risk/benefit, especially in the non-elderly. The risks for children clearly outweigh the benefits.
  • Repeated COVID-19 vaccine booster doses appear to induce tolerance and may contribute to recurrent COVID-19 infection and ‘long COVID’.
  • The SARS-CoV-2 pandemic has revealed deficiencies in public health and medicines regulatory agencies.
  • A root cause analysis is needed for what now appears a rushed response to an alarming infectious disease pandemic.
  • Treatment modalities for ‘spikeopathy’-related pathology in many organ systems, require urgent research and provision to millions of sufferers of long-term COVID-19 vaccine injuries.

Free PMC article

Ist COURSE OF PERSON-CENTERED PREVENTION AND TREATMENT OF COVID 19

The Medical School of Milan of the Ambrosiana University, with the Patronage of the Italian National Health Committee, organized the   specialization course,  dedicated to family and public health physicians  on the theme:

“Prevention and person-centered treatment of COVID-19 by variants of SARS-COV 2 and communicable diseases”

The course is the first edition in Italian of a European and international teaching program on the prevention of COVID-19, inspired by the Person-Centered Medicine application in theory and Medical Education, of which the Medical School of Milan of the Ambrosiana University is a pioneer and recognized world leader by the WHO. The course is aimed at teaching the correct epistemological and scientific paradigm to cope with the SARS-VOC 2 pandemic, based on the new antiviral allostasis and preventive immunostimulation paradigm, before a mass vaccination with genotoxic mRNA and vectorial vaccines also administered to children, adolescents and young people, not at risk of serious infections, if healthy. These mRNA and vector vaccines, inducers of an epigenetic earthquake, would have required years of experimentation to study even fatal adverse effects with serious damage to the health of the world population. The Course is coordinated by prof. Giuseppe R.Brera, currently the world’s leading expert on the prevention of COVID-19- wrote the only existing treatise on the subject and is the author of the theoretical paradigm of Person-Centered Medicine- is given by Maria Rita Gismondo, (Milan State University) virologist of international fame, Maurizio Federico, ( Director in the Italian Health Institute of the World Center of Global Health) who has in testing a pan-vaccine against the COVID-19, Salvatore Chirumbolo (University of Verona)  and Sergio Pandolfi  (University of Pavia) the most important Italian scholars on the early therapy of COVID-19, and the clinical “heresy” of the former Italian Health Minister’s, Roberto Speranza, illiterate paradigm” Paracetamol and vigilant wait” that cost thousands of deaths and hospital admissions. Medical Education is coordinated by prof. Vito Galante of the Milan School of Medicine with the quality procedure of the Ambrosiana University.

PROGRAM (1st edition-Italian)

Information to subscribe the European and International edition

communication@scuolamedicamilano.it

 

J Mazetes -Managing editor

The success of a pleiotropic integrated therapy against COVID-19

The success of a translational integrated therapy against COVID-19

Reading time: 9″

10.13140/RG.2.2.15071.12964/1

Giuseppe R.Brera*

A sixty years old unvaccinated woman, a great smoker, with a determinate temperament and basic trust, and a previous history of breast cancer with a swab positive diagnosis of COVID-19 developed a
temperature of 40 degrees, with headache and cough, an indicator of a high cytokine storm. She received an integrated therapy based on translational medicine structured on well-studied natural pleiotropic molecules
integrated with Nimesulide and Doxiciclin. The woman recovered from the severe COVID-19 syndrome in four days and joined the swab negativity in 10 days from the beginning of symptoms returning to work on the 11th day.

Article

  • Milan School of Medicine-Università Ambrosiana- Milano

 

Mass vaccination, the first time used to prevent a pandemic but with experimental mRNA and vectorial vaccines dangerous at the epigenetic-genetic level,[1] [2] [3] [4] and offered to the market with unreliable clinical research methods [5] [6] , and producing high rates of adverse effects and mortality, met in a minority of people also physicians and investigators a right diffidence and prudency to vaccinate people and themselves. These sera should have requested larger samples and a long time to be studied. The basic epistemological error caused by the lack of adoption in public health of the paradigm change of medical science and medicine, Person-Centered Medicine, must find an effective and cheap alternative allowing people primarily in countries with poor financial resources to prevent and care for viral and bacterial infections. To date, the deterministic-mechanistic paradigm used to cope with the pandemic implementing only biotechnology and profit is “Pathogen= mortality risk! and not the right indeterministic multidimensional one:” Pathogen-anti-pathogen allostasis = immunity-resilience- recovery”.[7] According to the Person-centered medicine primary prevention and therapy paradigm,clinical efforts must be addressed to improve life quality and psycho-biological resources to prevent and care for diseases and not to be problem-centered which improves only the disease-centered stock market. The World Health Charter should be adopted worldwide.

Anti-viral drugs and monoclonal antibodies are developed through fragmented research methods and show dangerous adverse effects while there are in nature pleiotropic, powerful and cheap molecules that, without adverse effects act contemporary at a biochemical and immunological level showing a great preventive action and efficacy and therapy. This is the road map for prevention and therapy based on the physiology revolution of “allostasis” (Sterling and Heyer) [8] substituting the obsolete concept of “Homeostasis”(Cannon) taught yet and unknown to most clinicians and investigators.

The anti-viral targets of prevention and a successful therapy anti-SARS-COV 2 variants of concern (VOC) must be addressed at the same time to prevent the virus binding to receptors, (barrier effect) inhibition of proteases, prevention of NK and CD8inactivation by viruses, re-activation of the P53 gene, preventing the critical anergy after the seventh day of the disease shared by patients with atherosclerosis -based comorbidities, reinforcement of natural humoral immunity, and prevention of the virus-induced viral allostatic metabolism and generation of anti-viral allostasis, prevention of cytokine storm-induced lung inflammation and antiviral allostasis in oral, nasal mucosae and upper respiratory ways, and an antiviral allostasis metabolism generation.

One of us recently introduced to the COVID prevention and early treatment of the epistemological concept of anti-viral allostasis and immunostimulation identifying the relativity of the SARS-COV 2 entry into cells and reviewing the anti-viral targets of naturals molecules spread worldwide [9] [10]  according to the Person-centered prevention strategy” inspired by Person-Centered Medicine, the current paradigm of Medical Science, [11] [12]  which at the clinical level introduced the Person-Centered Clinical Method that allows the physician the identification of the subjective-biological-environmental patient’s resources addressed to improve the person and lifestyle, [13]   not reducing the clinical case to be a probabilistic event of a natural law variation, [14] but concerning the relation with the person’s subjective being, comprising in existence and resulting in life quality related to the spiritual- psycho-neuro-endocrine, immunity  [15], and epigenetic individual system.

The COVID-19 prevention and early treatment inducing an anti-viral allostasis (AVAL) and immunostimulation (IMUST) is entrusted to the person’s natural immune system and can be reinforced by a resource-centered healthy lifestyle and powerful anti-viral substances with act as natural epigenetic programmers at immunity -biochemical level. Nutrition quality is part of a healthy or bad life quality. Curcumin, Aloe, Lactoferrin, Epigallocatechin, Beta-glucans Sphingosine, Mannan binding lectins, and Quercetin are natural molecules with a well-documented powerful pleiotropic antiviral allostasis and immunostimulant actions  [16] [17] . Vit A and C are immunostimulants and VIT D metabolite, [18] cathelicidin has direct virucide properties. Nimesulide has stronger anti-inflammatory and antiviral properties, with well-studied significant therapeutic successes,[19] and its association with maltodextrins results also in immunostimulation. [20] [21]  Doxiciclin has also antibacterial and antiviral properties. [22] Conversely the antipyretic tachipirine, suggested by the Italian Health Ministry to treat early COVID is dangerous because it promotes coagulation and has not ant-inflammatory effects. [23]

A sixty years old unvaccinated woman, a great smoker, with a determinate temperament and good basic trust, and a previous history of breast cancer with a swab positive diagnosis of COVID-19 developed a temperature of 40 degrees, with headache and cough, an indicator of a high cytokine storm. Tachipirin administration, prescribed by phone by an emergency unit according to the Italian health ministry indications was suspended and a translational therapy integrated with drugs was prescribed with the resolution of COVID-19 syndrome in four days and negativity of swab in 10 days. The woman started to work on the 11th day. Posology is indicated in table 1 (Table 1)

Genotoxic and immunosuppressive mRNA and vectorial vaccines, silencing microRNA and/or hybridizing DNA [24]  produce only circulating IGG, waning in a short time and are inactive against VOC not induce protective mucosal IGA and do not generate Memory B Cell in lungs [25]  with a high rate of life-threatening adverse effects. Cells’ methylation induces an increased risk of cancer. [26]     Monoclonal antibodies and anti-viral drugs have many adverse effects and are expensive, while translational medicine and its integration significant could promote effective prevention and therapy worldwide at low cost with high availability of natural anti-viral molecules. Moreover, there is the impossibility to vaccinate the entire world, and integrated therapy could offer cheap possibilities to all for self-care through health education. Person-centered translational prevention and therapy based on preventive antiviral allostasis and immuno-stimulation and self-care in poor countries all over the world, by correcting the epistemological error determining the failure of the pandemic prevention  is a new perspective for public health to prevent communicable and non-communicable diseases worldwide, without submitting people to experimental mass vaccines.

 

[1]    Lockhart J, Canfield J, Mong EF, Vanwye J, Totary-Jain H. Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019;14:339-350. doi:10.1016/j.omtn.2018.12.00

[2]   Doerfler W. Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. doi: 10.1016/j.virusres.2021.198466. Epub 2021 Jun 1. PMID: 34087261; PMCID: PMC8168329.

[3]    Seneff, S., Nigh, G., Kyriakopoulos, A. M., & McCullough, P. A. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Food and chemical toxicology 2022; 164, 113008. Internet:https://doi.org/10.1016/j.fct.2022.113008

[4]    Brera G.R. Scientific evidence of mRNA and vectorial vaccines genotoxicity inducing tumors and psycho-neuro-behavioral disorders. Scientific Report of the Milan School of Medicine; December 7 2021 DOI: 10.13140/RG.2.2.29151.18081

[5]    Cotton C. Lecture méthodologique desrésultats des essais cliniques des vaccins COVID-19. Internet   https://www.francesoir.fr/sites/francesoir/files/media-icons/Revue-des-Essais-Cliniques-COVID-Christine-Cotton.pdf

[6]    Cotton C. Evaluation des pratiques méthodologiques mises en œuvre dans les essais Pfizer dans le développement de son vaccin ARN-messager contre la COVID-19 en regard des Bonnes Pratiques Cliniques Présentation OPECTS Christine COTTON 1 A Maxime Beltra Christine COTTON – 05/04/2022 – © L

[7]     Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432

[8]    Sterling P.,Eyer J. Allostasis: a new paradigm to explain arousal pathology. In: Fischer S Reason J. editors. Handbook of Life Sciences, cognition, and Hea[7] Robinson E.G., Fernald R., Clayton D. Genes and Social Behavior.Science 2008;322:896-lth. New York 1988: J.Wiley and sons;p. 629-649

[9]    Brera G.R. SARS-COV 2 allostasis and the people and person-centered prevention. A new prevention strategy based on people’s metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Università Ambrosiana , 2021. ISBN: 9798530093906

[10]    Brera G.R . SARS-COV 2- allostasis and the people   and person-centered prevention.  Part 2 The Sars-Cov 2- induced immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation -How to induce zero risk for covid-19. Milan:  Ambrosiana University: 2021. ISBN: 9798547583520

[11]   7

[12]   Brera G. R, The manifesto of Person-Centred Medicine. Medicine, Mind and Adolescence 1999.XIV, 1-2:7-11

[13]  Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432

[14] Gadamer H-G Where health is hidden. Frankfurt; Suhrkamp Verlag, 1993 (German)

[15]  Lissoni P The spirit marries the science. Calco, Ripamonti tip, 2008 (Italian)

[16] 8-9

[17]  Qingqing Dai, Yasumasa Morita, Yongbo Huang, et al) Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles. Journal of Inflammation Research. 2019; 12: 335-343

[18]  Mitra S, Paul S, Roy S, Sutradhar H, Bin Emran T, Nainu F, Khandaker MU, Almalki M, Wilairatana P, Mubarak MS. Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review. Molecules. 2022 Jan 16;27(2):555. DOI: 10.3390/molecules27020555. PMID: 35056870; PMCID: PMC8779769.

[19]  Suter F, Consolaro E, Pedroni S, et al. A simple, home-therapy algorithm to prevent hospitalization for COVID-19 patients: A retrospective observational matched-cohort study. clinical medicine. 2021 Jul;37:100941. DOI: 10.1016/j.eclinm.2021.100941. Epub 2021 Jun 9. PMID: 34127959; PMCID: PMC8189543. (Medrix 25/03/2021

[20]  Gozzi-Silva SC, Teixeira FME, Duarte AJDS, Sato MN, Oliveira LM. Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve? Front Nutr. 2021 Sep 7;8:674258. doi: 10.3389/fnut.2021.674258. PMID: 34557509; PMCID: PMC8453008.

[21]   Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc. 2005;2(5):403-11.  DOI: 10.1513/pats.200508-090JS. PMID: 16322590; PMCID: PMC2713330.

[22]  Dorobisz K, Dorobisz T, Janczak D, Zatoński T. Doxycycline in the Coronavirus Disease 2019 Therapy. Ther Clin Risk Manag. 2021 Sep 21;17:1023-1026. doi: 10.2147/TCRM.S314923. PMID: 34584416; PMCID: PMC8464303.

[23]  Pandolfi S, Simonetti V, Ricevuti G, Chirumbolo S. Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients? J Med Virol. 2021 Oct;93(10):5704-5706. doi: 10.1002/jmv.27158. Epub 2021 Jun 30. Erratum in: J Med Virol. 2022 Mar;94(3):1246. PMID: 34170556; PMCID: PMC8426871.

[24]   1-2-3-4

[25]  Federico M. Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody Production. Journal of Immunology Research. 2022. DOI  https://doi.org/10.1155/2022/4028577

[26]  Huang L, Liang D, Zhang Y, et al. METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b. J Cancer Res Clin Oncol. 2022 Nov 8. doi: 10.1007/s00432-022-04429-9. Epub ahead of print. PMID: 36348020.

 

 

 

 

 

 

 

 

 

Table 1

 

 Substance-molecule   Posology
   Curcumin Curcumin 500 mg x2

5’Inhalation of turmeric powder (10 g- two tea spoons) vapors  from a solution with 100 ml of water at boiled temperature
Aloe extract  50 ml x 2
Lactoferrin 200 mg x 2 before meals
Epigallocathechin  Infusion of green tea (40°) four glasses per  day ( 800 ml )
Resveratrol 1000 mg x 2 before meals
Sphingosine and Beta-glucans Kefir milk 200 ml x 3
Melatonin 5 mg ( evening
Vit D10 10.000 U ( 7 days) after  1000
Vit, C 500 mg
Vit A 1000 U
Nimesulide and maltodextrins 400 mg x 2
Doxiciclin 200 mg a day
Table 1  Posology of the integrated therapy-

( Doses are referred one-two times a day ,morning and evening)

 

 

A RESEARCH MANIFESTO FOR THE WITHDRAWL OF ANTI-COVID 19 mRNA AND VECTORIAL VACCINES

The COVID-19 pandemic finds its basis in the epistemological error imperant in medicine and public health: To date, the obsolete and wrong deterministic-mechanistic paradigm used to cope with the pandemic implementing only biotechnology and profit is “Pathogen-infection- mortality risk” and not the right indeterministic multidimensional one:” Pathogen-anti-pathogen allostasis = antiviral metabolic allostasis and immunity stimulation -resilience- recovery.” the basis of Person-Centered Medicine that states that health is: ” The choice of the best possibilities for being the best human person.” Truth, freedom, and health are inseparable.

( Brera, G.R. Person-Centered Medicine and Person Centered Clinical Method. Milano: Università Ambrosiana ed.: 2021 ISBN: 9798726465432)

The error led to the omission of secondary prevention, which should have been based on research on the first 2002 SARS-COV and 2009 MERS disappeared without mass vaccination.

The error leads to the omission of secondary prevention in the oldest people at risk with comorbidities (93% of deaths).

Genotoxicity due to the silencing of mi-RNA to promoter genes by mRNA vaccines but to date has not yet been investigated in their epidemiological consequences. There is evidence of risk of mortality, cardiovascular and oncological morbidity after vaccination, and a high-risk index for adverse effects, including increased vulnerability to cancer, autoimmune diseases, and cardiovascular diseases. These data call for the immediate withdrawal of mRNA sera worldwide.

Immunodepression induced by multiple injections of mRNA vaccines has been demonstrated. In fact, after two doses, the unvaccinated are more protected from infection than the unvaccinated.

( Lancet: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2822%2900089-7).

Moreover, there are no” large differences in the median duration of viral shedding among participants who were unvaccinated, those who were vaccinated but not boosted, and those who were vaccinated and boosted.” Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron…

These observations, along with the AB mRNA vaccines waning and the lack or weak presence of IGA in mucosae of upper respiratory ways, make the persecution made by some countries against prudent unvaccinated health professionals a delusion of illiterate governments that prescribed an obligement to vaccination.

Vectorial sera have a great probability of hybridizing human DNA and present risk of autoimmunity and induced cardiovascular pathologies up to death like mRNA.

There are other forms of prevention and easy treatment of COVID-19 in the early stages that make them useless. The state of Florida (USA), having found a risk of 2.3 for mortality in subjects vaccinated by mRNA sera with an 83% increase in mortality under 39 years, has prohibited them. Swede, Denmark, and Canada, respectively. didn’t recommend vaccination under 19-50-60 yo. The induction of children and young people’s vaccination is a crime against humanity motivated only by profit and power, as the Nobel prize Luc Montagnier agreed.

The 2002 SARS-VOC epidemics and the 2010 MERS have disappeared without mass vaccinations in a year. Mass vaccinations, in addition, in times of epidemic, select increasingly dangerous variants for the evasion of the immune system, an enormous business for BIG PHARMA.

.

This letter is intended to propose to Research Gate researchers a World Manifesto for the withdrawal of mRNA vaccines from the market as follows.:

“Researchers of the Research Gate, by highlighting the danger of mass vaccination and boosting with mRNA and vectorial sera for the world health people, make an appeal to governments for their withdrawal from the market and the withdrawal by governments of vaccination obligations. RG researchers, moreover, make an appeal to suspend any crazy suspension from the work of unvaccinated health professionals because of the lack of any scientific motivation and the result of governments’ illiteracy which led to a violation of human rights.”

Adherence to the World Manifesto takes place through adherence to this initiative in the discussion and mail to

researchgatemanifesto@worldhealthcommittee.net

, subscribing to the site and supporting this initiative if you agree.

Attend to the discussion on www.researchgate.net

Giuseppe R. Brera

President of the World Health Committee

www.worldhealthcommittee.net

President of the Italian National Health Committee

www.comitatosanitarionazionale.it

Director of the Milan School of Medicine

www.scuolamedicamilano.it

 

DEMOLISHED THE WHO’S HEALTH STRATEGY AGAINST COVID-19 AND COMMUNICABLE DISEASES

 

One treaty and a book demolished the global biotech policy against the COVID-19variants’ pandemics blessed by WHO  and piloted by the profit  BIG-PHARMA organizations  and introduced a new real and effective person-centered health global policy that induces the prevention of communicable and non-communicable diseases.herly, Christine Cotton highlighted omissions and the errors in mRNA vaccine experimentation that make these unreliable and dangerous for people.

Recently Seneff, S., Nigh, G., Kyriakopoulos, A. M., & McCullough, P. A. et al. highlighted the innate immune suppression by SARS-CoV-2 mRNA vaccinations. In 2019  Lockhart J, Canfield J, Mong EF, Vanwye J, Totary-Jain H. highlighted the nucleotide modification  that alters microRNA-dependent   Silencing of MicroRNA switches. This last paper has been ignored by public health supporters of the global vaccination, involving children, adolescents, and young people not at epidemiological risk and submitted to severe and frequent adverse effects up to death.

Furtherly, vaccination of oncologic patients increases infections, hospitalizations, and deaths, confirming the mRNA vaccine immune-depression induction that adds it to the chemotherapy effects on immunity as highlighted by Wang W, Kaelber DC, Xu R, Berger NA

There is an urgent need in all countries to convert the health policy to adopting person-centered prevention based on the antiviral allostasis and preventive immunostimulation, as extensively highlighted by prof. Brera’s books are introduced here.

The public health assessors should be morally motivated to change health policy by adopting the paradigm change of Medicine: “Person-Centered Medicine.” if they want to be honest with people, a rare event of lighted people.

 

  1. PERSON-CENTERED MEDICINE AND PERSON-CENTERED MEDICINE CLINICAL METHOD

CLINICAL RESULTS OF THE FIRST MEDICINE UNITARY PARADIGM TEACHING AND THE SARS-COV 2 ENTRY RELATIVITY INDUCING PERSON.CENTEReD PREVENTION  THEORY

Author: Giuseppe R.Brera

Editor: University Ambrosiana

147 pages,  $ 28  

distributed worldwide by Amazon

 

The book introduces the Person-Centered Medicine theorized by Giuseppe R.Brera and taught at the Milan School of Medicine in PG medical education.

The book introduces the PCM paradigm and, step by step, the Person-Centered Clinical Method clinical application that has revolutionized the traditional clinical method only centered on empirical observations and clinical application results from its teaching to physicians.

The author introduces the Person-Centered Theory of Health Relativity and highlights the WHO’s epistemological error in the prevention policy of COVID-19.

In chapter 6; The SARS-COV 2 allostasis theory and the COVID-19 mechanic primary prevention failure, the result of a guilty omission of secondary prevention, the author introduces the SARS-COV 2 infection relativity   and “Complication probability theories” highlighting People and Person-Centered paradigm of prevention

 

  1. SARS-COV-2 ALLOSTASIS AND THE PEOPLE AND PERSON-CENTERED PREVENTION

A NEW PREVENTION AND TREATMENT STRATEGY BASED ON THE PEOPLE METABOLIC AND  IMMUNE SHIELD FOR THE PANDEMIC SHUTDOWN

PART 1

THE SARS-COV 2 ENTRY RELATIVITY AND COVID-19

19  July 1, 2021

Author: Giuseppe R.Brera

Editor: University Ambrosiana

Pag 125    $   25    

Distributed worldwide by Amazon

 

In the first part of the treatise, “The virus entry,”  the author had demonstrated how the SARS-COV 2 virus enters cells through pathological cell membranes characterized by lipid degeneration, thus explaining the vulnerability of the elderly with comorbidities that have atherosclerosis and protection against infection in young people as their common denominator. Adolescents and children are not subjected to immunosuppression due to a lack of alteration in the transduction of immune signals and the preserved validity of innate humoral and cellular immunity, verified by epidemiological research.

Professor Brera theorized an equation of relativity of the infection and probability theory of its severity, opening up a new perspective of prevention, capable of identifying subjects at risk of as severe COVID-19, intensive care, and death.

 

  1. SARS-COV 2- allostasis and the people and person-centered prevention.

 Part 2 The SARS-COV 2- induced  immunosuppression and covid-19 anergy

Part 3 The antiviral metabolic allostasis and preventive immunostimulation  -How to induce zero risk for covid-19.

 University Ambrosiana: 2021   332 pag.  611 references”

Author Giuseppe R.Brera

Editor: University Ambrosiana

Pag. 328   $ 50

Distributed worldwide by Amazon

 

In the second part of the treaty, the author deepened the new person-centered biochemical-immunological-virological perspective of viral allostasis that he had introduced. The author discusses the relationship between atherosclerosis, immunosuppression, and immune anergia in people at risk, leading to lethality.

The treaty completely falsifies the bio-tech prevention strategy addressed to multiple vaccinations of the elderly and in comorbidities with or without atherosclerosis. Immunosenescence and the immunosuppressive phenotype of atherosclerosis result in a reduction of induction of immune memory induced by non-proliferation and activation of T and B cells and induced cellular immunity, with waning immunity in a short time not protecting the lung and mucosal epithelium. The lethality of vaccinated older adults with comorbidities is on the news, and the natural immunity of children and young people, determining the lowest epidemiological risks and the mRNA adverse effects up to lethality, should have determined the choice to non-vaccinating them.

The treaty shows that the government’s policy of vaccinating young and oldest people with many shots is wrong at the epistemological and scientific levels. This policy requires a total change of preventive strategy and effective early care, moving to antiviral allostasis and preventive immunostimulation with the resignation of the public health organizers. In 2020-2021 millions of people’s deaths confirm the WHO’s and global policy failure. Wrong prevention and lethal strategy based on dangerous vaccines alter cells’ epigenetics by inducing micro-RNA suppression, immunity, depression, tumor vulnerability, and neurobiological alteration. There could be a relation between diplomacy failure in the Russia-Ukraine conflict and vaccines-induced brain alteration in European-NATO and world leaders.

Astra-Seneca’s vectorial Chimpanzees’ adenoviruses are in the DNA of many world leaders and diplomacy people, and micro RNA silencing by mRNA vaccines alters brains. The errors  and omissions in the  mRNA vaccines’ experimentation, well highlighted by Christine Cotton, furtherly introduce the permanence of the biotech addressed global policy against communicable diseases blessed by WHO as a profit-induced lethal fraud,

In the third part of the treatise, the author profoundly analyses the biochemical and immunological action (130 pages) of the potent antiviral and immuno-stimulant and immunogenic properties of an easy diet containing particular natural metabolites and nutraceutical supplements. The diet-induced antiviral allostasis cancels the risk of infection by Sars-COV 2 variants and many viruses, suggesting the validity of primary and secondary prevention based on antiviral allostasis and preventive immunostimulation through health education and self-care that would have led to the block of onset of the pandemic saving millions of lives-including 150,000 in Italy. “Antiviral allostasis” is a word unknown to public health organizers for epistemological ignorance of the healthy ministerial intelligence and world media virologists-immunologists, inducers of a new branch of criminality: “The virologists’ terrorism.”

The treatise theorizes the foundations of the antiviral strategy and preventive immunostimulation,  not only for SARS-COV 2 but for many other viruses and non-communicable diseases such as cancer that share in the first phase of infection metabolic alterations (1) of SARS-COV 2 and that the World Health Committee is launching in the world as the only possibility to prevent further epidemics. Mass vaccination induced the production of variants and immunity depression, as demonstrated by the epigenetic alterations caused by RNA vaccines transmitted to the offspring. These alterations pose challenging questions about the present and future effects on the brain and immunity and, therefore, on vulnerability to learning difficulties and mental health, tumors, and auto-immunity for DNA and hybridization by vectorial and mRNA vaccines

These irrefutable data present situations of obligation to the choice of vaccination and its imposition  (Green Pass),  the induction to the vaccination of children and adolescents-young, also cause of deaths- as an expression of a real illiterate and insane abuse of power.

The treatise-  is inspired by the Person-Centered Medicine change of paradigm of medical science, of which the author is the main inspirer in the world and lecturer at the Medical School of Milan.

In the introduction, Prof. Brera presents the conflict between a preventive-therapeutic biotechnological approach to the pandemic, only necessary tool but not the meaning of Medicine, and the person-centered change of paradigm of the concept of Medicine and Health,  to date defined as ” The choice of the best possibilities to be the best human person,” also political program, basis of the “Charte Mondiale de la Santé” – “The World Health Charter” presented in Milan in 2017.

The treaty lays the scientific foundations of the world health development program, called the ” People and Person-Centered Prevention Program,” promoted worldwide by the World Health Committee, and promotes the Person-Centered medicine paradigm spreading in public health.

The health policy promoted by the treaty is the exact opposite of health programs centered on “mechanistic-bio technological therapies and preventions,” which override man’s fundamental right to freedom to choose what is most appropriate for personal health. This strategy induced a criminal vaccination of children and adolescents, without an epidemiological justification, with specific and even fatal adverse effects, and states’ dependence on health merchants and vaccines,  interested in having a mass of chronic sufferers for profit reasons.

Members of the consortium of the multinational drug companies were also able to falsify scientific data to sell, as it appeared from the $250 million penalties given to Smith-Kline and Becham from the FDA in 2014 and present experimental programs of SARS-COV 2 vaccines of limited and wrong validity, omitting the study of adverse effects of vaccines.

 

 

by  I. Mazethes, WHC  editorial manager

 

 

 

 

Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Mortality in Vaccinated Patients With Cancer

 

William Wang , David C. Kaelber; Rong Xu, et al in an article on JAMA  oncology on April 8,  have irrefutably highlighted that the mRNA vaccination anti COVID increases the rate of infection, hospitalization, and mortality in cancer patients.
The research, a retrospective cohort study on 2020-2021 vaccinated cancer patients,  in the USA, comparing 45 253 vaccinated cancer patients, with 12 common neoplastic diseases including hematological ones, with healthy vaccinated (total sample of vaccinated with two doses of Pfizer or Moderna n=636.435), showed a significant increase in infections, hospitalizations, and mortality in neoplastic patients.

“Among 45 253 vaccinated patients with cancer (mean [SD] age, 68.7 [12.4] years), 53.5% were female, 3.8% were Asian individuals, 15.4% were Black individuals, 4.9% were Hispanic individuals, and 74.1% were White individuals. Breakthrough SARS-CoV-2 infections in patients with cancer increased from December 2020 to November 2021 and reached 52.1 new cases per 1000 persons in November 2021. The cumulative risk of breakthrough infections in patients with all cancer was 13.6%, with the highest risk for pancreatic (24.7%), liver (22.8%), lung (20.4%), and colorectal (17.5%) cancers, and the lowest risk for thyroid (10.3%), endometrial (11.9%), and breast (11.9%) cancers, vs 4.9% in the noncancer population (P < .001). Patients with cancer had significantly increased risk for breakthrough infections vs patients without cancer (HR, 1.24; 95% CI, 1.19-1.29), with greatest risk for liver (HR, 1.78; 95% CI, 1.38-2.29), lung (HR, 1.73; 95% CI, 1.50-1.99), pancreatic (HR, 1.64; 95% CI, 1.24-2.18), and colorectal (HR, 1.53; 95% CI, 1.32-1.77) cancers and lowest risk for thyroid (HR, 1.07; 95% CI, 0.88-1.30) and skin (HR, 1.17; 95% CI, 0.99-1.38) cancers. Patients who had medical encounters for cancer within the past year had higher risk for breakthrough infections than those who did not (HR, 1.24; 95% CI, 1.18-1.31). Among patients with cancer, the overall risk for hospitalizations and mortality was 31.6% and 3.9%, respectively, in patients with breakthrough infections, vs 6.7% and 1.3% in those without breakthrough infections (HR for hospitalization: 13.48; 95% CI, 11.42-15.91; HR for mortality: 6.76; 95% CI, 4.97-9.20)”

The significant increase in infections, hospitalization and mortality in vaccinated cancer patients could be explained in a multifactorial way by the decrease in the immune capabilities of cancer patients due to chemotherapy and the inhibition of immunity made by mRNA vaccines due to the silencing of tumor suppressor genes ( P 53), by the inactivation of microRNAs and by the inhibition of MHC2 necessary for the activation of cellular immunity (e.g. cytotoxic lymphocytes).
The inhibition of immunity is therefore proportional to the number of doses of mRNA vaccines, and immunosenescence and is also caused by atherosclerotic comorbidities. mRNA vaccines expose the population to greater vulnerability to cancer, and infections as highlighted by prof. Giuseppe R. Brera, in his work on the genotoxicity of mRNA vaccines and in his treatise that introduced the antiviral Allostasis and the preventive Immunostimulation to prevent infections by variants of SARS-COV 2.

The only possibility for cancer patients and the population to prevent infections by variants of SARS-COV 2 and increase defenses against neoplasms is antiviral allostasis and preventive immunostimulation also active against all communicable diseases and cancer.

 

JM  WHC Editorial Manager

THEORIZED THE RELATIVITY OF SARS-COV ENTRY AND COVID-19 SYNDROME TO CELL MEMBRANE’S CHOLESTEROL-INDUCED LIPID RAFTS

 

 

The Ambrosiana University has edited a treatise on SARS-COV 2 by Professor Giuseppe R.Brera, director of the Milan  School of Medicine  and president of the International Committee for the change of the paradigm of health and medicine. The treatise introduces into virology the revolutionary physiological concept of “Allostasis”, hitherto unknown to most virologists, clinicians and researchers, and recently the subject of an international conference on its importance for the paradigmatic change of medicine. The treatise, the first in the world, addresses the scientific and clinical approach to infection in a new multifactorial perspective, integrating the experimental and clinical investigations of SARS-COV and SARS-COV 2 in virology, immunology, epidemiology biochemistry. This impressive theoretical work on more than 1000 experimental and clinical investigations since 2002, forms the basis of a new approach to the pandemic called: “Person-Centered Prevention and Infection Early Treatment according to “Person-Centered Medicine”, which since 1999 has revolutionized medicine and medical science and since then taught at the School of Medicine in Milan.

In the treatise, Prof. Brera introduces the theory of relativity of virus entry into cells through an alteration of the membrane structure induced by cholesterol and the consequences, even fatal, of infection, due to atherosclerosis resulting in innate and adaptive immunity depression and an abnormal reaction induced by the immune phenotype to viral antigen stimuli. The theory explains the vulnerability of patients with co-morbidity characterized by atherosclerosis and the innate immune protection of children and young people (up to 30 ) who do not need any vaccination.

The entry of the virus into cells  is conditioned by the “lipid rafts” where the virus with the ACE 2 receptors and other transmigrates for endocytosis..

The signal deviation induced by LDL cholesterol in the “lipid rats” of atherosclerotic patients induces an immune phenotype favoring the fatal immune anergy after the seventh day easily detectable and preventable, strategy so far omitted with a fatal error of the WHO and most health governments of the countries, error paid by millions of people.

The theory of the relativity of SARS-COV 2 infection is crucial to change the prevention strategy and free humanity from the nightmare of SARS-COV 2 and its variants. It allows for the preventive detection of people vulnerable to infection and directs to primary and secondary prevention based on the reinforcement of immunity, a strategy omitted by the fatal ignorance of public health managers that caused more than a million deaths. Epistemological and scientific illiteracy has been paid by the world and Italian population but has been well supported and practiced by most of the world governments and the WHO. In Italy, this is the main cause of the request of the “National Health Committee” for determined action to induce the resignation of the Minister of Health Roberto Speranza.

The treatise was preceded by another book by the same author, Person-Centered Medicine and Person-Centered Clinical Method, the application of which leads to saving people’s suffering and the health costs of countries in a meaningful way as it appears from the data published in the book. Here the author also presented the epistemological basis of the new concept of health, and a chapter highlights the necessary pathways of entry of SARS-COV and the development of COVID-19 , also discussing the scientific probability of induction of cancer of vaccines against SARS-COV mRNA. This essay and the treatise are a crucial contribution to addressing any prevention and treatment of any pandemic, underpinning the strategy of the “Person-Centred Prevention Programme””, which orients public health to health promotion, education, health education, self-treatment and induced cross-prevention with other communicable and non-communicable diseases.

These books indicate that the most dangerous pandemic seems to be epistemological ignorance of the changing paradigm of Medicine..  This delay has led to a mono-dimensional, failed  virological approach to the pandemic, aimed only at inducing mechanistic prevention-wrong biotechnology and human rights violations and an economic failure of the countries that is causing the poverty of millions of people. The establishment by Europe and some European countries of a “Green Pass” for vaccinated people is without any scientific foundation because vaccination does not prevent infections and contagion.  Vice versa,  from 2002 to 2020, the multinational vaccines have not produced any vaccine because of the frequent mutations of the virus. The theory of relativity SARS-COV 2 refutes the erroneous mechanistic-determinist  and linear causality model, in coping to COVID-19 promoted by the WHO and many countries, omitting secondary prevention. This wrong approach caused more than a million deaths because it pushed primary prevention only to biotechnological measures, excluding people’s health education to an immuno-empowering and anti-viral quality of life. This omission based on ignorance gets to expose children and young people, completely protected by innate immunity, or elderly immunosenescent, with innate and adaptive immunity depression, to experimental vaccines with limited validity over time and completely useless against variants, with short and long-term risks of adverse effects until death.

The treatise is edited at the same time as the International Conference: for the 26th anniversary of the opening of the Ambrosiana University:

The paradigm shift centered on the person’s health and medicine paradigms and COVID-19

where the most significant  scientists contributors of the paradigms change of medicine and health explained the scientific basis of the transition from the dominant deterministic and one-dimensional paradigm-mechanistic to the new and its omission related to the development of the SARS-COV 2 pandemic.

 

References

 

Giuseppe R.Brera :Sars-Cov 2 allostasis and people and prevention centered on the person-A new prevention strategy based on the induction of people’s metabolic and immune shield for pandemic arrest COVID-19″ 632 p. – 1065 references.

First part: “The relativity of SARS-COV 2 entry and COVID 19 138 pp. euro 30 e-book and printed ISBN: 9798530093906

 

Giuseppe R.Brera: Person-Centered Medicine and Person-Centered Clinical Method- practical results of the paradigm of unitary medicine and the theory of prevention COVID-19 people and person-centered” – 131 p. -132 references euro 17 – e-book and print ISBN: 9798726465432

 

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PERSON-CENTERED MEDICINE , PREVENTION AND ADOLESCENCE

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DONATE TO MILAN SCHOOL OF MEDICINE

 

 

SCIENTIFIC EVIDENCE OF mRNA AND VECTORIAL VACCINES’ GENOTOXICITY INDUCING TUMORS AND PSYCHO-NEURO-BEHAVIORAL DISORDERS

 

 

Scientific evidence of anti -COVID 19 mRNA and vectorial  vaccines genotoxicity inducing tumors and psycho-neuro-behavioral disorders

  • November 2021

Summary

. Micro-RNAs (miR) are non-coding RNA filaments that control mRNA transcription. Micro-RNAs have been studied in cancer pathogenesis, metastasization, cancer therapy, the structuring of the central nervous system, diabetes, and heart disease.   Mir-134-138 regulate the development of dendritic spines needed for synapses. Their silencing can lead to autistic spectrum disorders and mental retardation and damage to brains in evolution such as childhood and adolescence, producing learning problems and mood problems, and in adults for alterations of receptors for neurotransmission.  It has been shown that N1-methyl pseudouridine binds to miR and induces silencing processes, increasing cell methylome at the origin of cancer. The production of mRNA vaccines replaces Uridine with N1-methyl-pseudouridine to escape innate immunity and implement rapid translation. N1-methyl-pseudouridine  binding with mi-RNA alters the epigenetic transcription of oncosuppressor that, with the increase in cell methylation, could result in the induction of tumors and relapses, natural immunity inhibition, and neuro-behavioral disorders transmissible to progeny. Vectorial vaccines hybridize the host DNA with adenoviruses and induce tumors at the experimental level. Clinical reports and long-term epidemiological investigations are necessary to verify the impact of mRNA vaccines on health.

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PERSON-CENTERED MEDICINE, PREVENTION AND ADOLESCENCE- CONGRESS

 

Inaugural Conference of  the 2020-2021  academic activities of Ambrosiana University

PERSON-CENTERED MEDICINE, PREVENTION

AND  ADOLESCENCE.

The Person-Centered Prevention Program  for pandemic prevention

Introduction

 

Person-Centred Medicine (PCM) is the current paradigm of medical science and Medicine, and this involves the orientation of public health with a new organization of primary care and the training of doctors and students in Medicine through teachers prepared for PCM teaching. Its application, through trained doctors, allows enormous savings in suffering and costs. The PCM reconverts health to “Person-centred prevention” by promoting health education, prevention, early treatment of diseases, self-care, incentivizing individual resources, introducing and reinforcing protective factors, and buffering risk factors to improve individual resilience.
The PCM paradigm is defined as” The choice of the best possibilities for being the best human person,” which is also a political program.
In adolescence, a period of spiritual and psycho-biological formation, the PCM assumes fundamental importance throughout life because it builds an indelible trace for the future.
The Congress is held in three parts: the first is dedicated to the scientific bases of the Person-Centered Medicine interactionist and teleonomic paradigm, which will be followed by a panel dedicated to the paradigm change of Medicine. (in English) -November 13
Keynote speakers: Peter Sterling, the author of the Allostasis theory that revolutionized physiology and medical science, the fundament of the Person-Centered Medicine paradigm with other significant contributors to Medicine paradigm change .(November 13- h 15)
The second session is dedicated to adolescence. Speakers are contributors to the revolution of the paradigm of the adolescence theory. (November 13- 17,30-19,30)
The third session is dedicated to the Person-Centered Prevention paradigm, genetic and epigenetic damages induced by vaccines against SARS-COV 2, and early treatment of COVID-19.
( November 20 – h 15 in Italian-English)
Giuseppe R.Brera
Rector of the Ambrosiana University, Director of the Medical School of Milan, president of the World Health Committee and the Italian National Health Committee
Free access on zoom on registration
send the registration communication@scuolamedicamilano.it
To give a contribution to the conference in panels (5-7′) send the enclosed abstract form to scientificsecretariat@unambro.it dr. Vito Galante within 7 November (1°-2° session, November 13 -3°session)

The conundrum of current anti-SARS-CoV-2 vaccines

 

The conundrum of current anti-SARS-CoV-2 vaccines

Maurizio Federico

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being distributed currently, have been designed to induce neutralizing antibodies using the spike protein of the virus as an immunogen. However, the immunological correlates of protection against the virus remain unknown. This raises questions about the efficacy of current vaccination strategies. In addition, safety profiles of several vaccines seem inadequate or have not yet been evaluated under controlled experimentation. Here, evidence from the literature regarding the efforts already made to identify the immunological correlates of protection against SARS-CoV-2 infection are summarized. Furthermore, key biological features of most of the advanced vaccines and considerations regarding their safety and expected efficacy are highlighted.

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