The conundrum of current anti-SARS-CoV-2 vaccines

 

The conundrum of current anti-SARS-CoV-2 vaccines

Maurizio Federico

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being distributed currently, have been designed to induce neutralizing antibodies using the spike protein of the virus as an immunogen. However, the immunological correlates of protection against the virus remain unknown. This raises questions about the efficacy of current vaccination strategies. In addition, safety profiles of several vaccines seem inadequate or have not yet been evaluated under controlled experimentation. Here, evidence from the literature regarding the efforts already made to identify the immunological correlates of protection against SARS-CoV-2 infection are summarized. Furthermore, key biological features of most of the advanced vaccines and considerations regarding their safety and expected efficacy are highlighted.

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Author: World Health Committee

The constitution of National Health Committees is addressed to institute in the world public health, in medical education, in biomedical research the Person-Centered Medicine paradigm according to the ethical and epistemological paradigm of “La Charte Mondiale de la Santè-the World Health Charter” (CMS-WHC) and the Universal Declaration for Freedom and Dignity; It realizes its objectives through the organization of Health National Committees

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