Under the Patronage  of the World Health Committee

                                          and “ Comitato  Sanitario Nazionale”  (Italy)       



3rd session : 20 Novembre 2021 - h 15-  Zoom


Introduction to the third session and welcome

Giuseppe R.Brera

Rector of the Ambrosiana University



Prof. Vito.Galante MD  PH D LD MA

Honorary Chair in Adolescentology  at the Ambrosiana University 

Scientific Secretary of the Congress               


Keynote lecture

“The Experimental Child”

Mental and Social Consequences for Children and Families  of the Coronavirus Syndemic      *

Vincenzo Di Nicola, MPhil, MD, Ph.D., FRCPC, DFAPA, FCPA, FCAHS

Honorary Chair (Licentia Docendi, LD) & Professor (Magister, MA Sc),  Ambrosiana University

Professor of Psychiatry, University of Montreal

Clinical Professor of Psychiatry, The George Washington University


Keynote lecture

Effects of current anti-SARS-COV 2 vaccines beyond antiSpike antibody generation

Maurizio Federico


National Center for Global Health

Istituto Superiore di Sanità (Italy) 

       Keynote lecture


Scientific evidence of epigenetic and genetic damages from anti-SARS-COV 2 vaccines and the epidemiologic confirmation of risks from vaccination.The need for the person-centered prevention paradigm inducing the “Antiviral allostasis and the preventive immunostimulation.

Giuseppe R.Brera MD, MA, MA LD

Director of the Milan School of Medicine, President of the World Health Committee 

and Italian National Health Committee


Discussion and free contributions (max7’)   

                                                           (In Italian and English)


1st  Workshop

of the



Roy Kallivayalil

Secretary-General of the World Health Committee


Giuseppe R.Brera

President of the World Health Committee

Contribution of  the  WHC Scientific Committee’s members 


Robert Cloninger, Claudio Violato, Richard Fiordo, George Christodoulou, Roy Kallivayalil, Giuseppe R.Brera


Contributions of invited speakers


End of the Conference

Giuseppe R.Brera

Rector of the Ambrosiana          

    The recent international conference :[1] in the third session dedicated to "Person-centered prevention, risks from genetic vaccines, early therapy of Covis-19" highlighted
  1. The "pandemic" must be renamed "Syndemic" because of theeffects on the      mental health of children and adolescents. We  face the phenomenon of the "Experimental child." ( V. Di Nicola)
  2. that infection with SARS-COV 2 and variants is dangerous only with comorbidity and affects 92% of people at risk. The increased risk of severity of COVID-19 is proportional to the increased comorbidity factors; (Antos A, Kwong ML, Balmorez et al- cit. Brera)[2
  3. that there is an increased risk of mortality in vaccinated older people, compared to non-vaccinated people with a seconddose before six months from the first; there is a tendency to an increase in risk in subjects between 12-39 years, and after the first dose in subjects 60-79;[3](from ISS raw data)[4]  (Brera-Violato) TAB 2
  4. that children, healthy adolescents, and young people up to 29 years of age are virologically not at risk of systemic cellular infection ( entry of the virus into all cells of the organism) due to the healthy conformation of cell membranes that prevent the entry of the virus into cells for the absence of "Lipid rafts" and are not "Untori" [5][6] [7][8] [9], indeed valuable artifacts of herd immunity. The rare and asymptomatic cases appear to be due only to virus-monocyte circulating plasmacytoid interaction and humoral immune reaction. The children and adolescents' humoral immunity power is confirmed by the fatality/case ratio 0 (Tab-1), while severe adverse effects after vaccination are frequent (9,3%) (Brera, Molteni, Byambasuren, Madewell, cit. Brera). Vaccination[10] resulted in deaths in healthy adolescents who would be alive if media would not orchestrate a campaign to induce them to vaccination;  (TAB 1)
  5.  that mRNA vaccines[11]are genotoxic, ([12] [13] [14]) because the substitution of an RNA base, the uridine with the pseudouridine, carried out in the production in order to avoid the natural immunity of the injected organism and the increase in the speed of the translation. The biochemical link induced by N1-methyl pseudouridine with micro-RNAs, causes their alteration and silencing, making the inoculated organism more vulnerable to solid tumors and leukemia, changes in the nervous system mental retardation, learning disorders, Asperger syndrome;  (Lockhart-Schratt-Raish-Zeng cit. Brera) 
  1.  cell methylation, induced by N1-methyl-pseudouridine at both epigenetic and genetic (DNA) levels, produces an additional risk factor for cancer vulnerability;[15][16](Li, Zeng cit.Brera 
  2.  that mRNA vaccines neither induce the synthesis of antiviral immunocytes (CD8 +) nor produce a memory of them;[17](Federico
  3. that mRNA vaccines do not affect the transmissibility of the virus and its variants because they do not induce the defense of IGA (antibodies to prevent the entry of the virus into the oral and[18]nasal mucous membranes; (Federico) therefore taking away any scientific validity to the establishment of the "Green Pass" as vaccinated and unvaccinated have the same probability of transmitting the virus
  4.  that the mRNA vaccines do not interact with other than the B cells of memory resident in the lungs, which are responsible for protecting against lung infections; [19](Allie cit. Federico), making vaccines not influential on infections of lungs by SARS-COV 2;
11.that SARS-COV 2 virus by nature and by vaccination induction is selecting     increasingly dangerous and immuno-resistant variants;[20] (Federico-Garcia);

 12. that the reduction in immunity induced by mRNA vaccines is constant until it drops to 16.1% of subjects below the 50% threshold after six months against 10.8% of those cured after nine months[21]of infection. . After six months, the level of IGG drops in vaccinated by 40% each month against less than 5% of convalescents (Israel-Federico);

13.that adenoviruses of vector vaccines hybridize with human DNA ( Astra-Zeneca-adenovirusof chimpanzee).[22]Furthermore, they increase[23] vulnerability to autoimmune diseases and tumors (experimental certainty). By activating the immune response of the organism against adenovirus- about 50% of the population is immunized- mRNA is destroyed and therefore do not produce immunity against Spike proteins, canceling their antigenicity and in children and adolescents can induce an immuno-complex disease and fatal thrombotic reactions, as already occurred in a teenager in Genoa (Doerfler cit.Brera).


                   Anti-COVID 19 genetic vaccines to date administrated to populations induce severe risks for people's health, primarily for children and adolescents not at risk of a rare severe clinical syndrome if healthy. In this age range, the objective COVID-19 possible severity is prevented by innate humoral immunity that does not allow the virus entering in cells and create the asymptomatic condition necessary for the induction of herd immunity.

    COVID-19 can readily be prevented by inducing a metabolic –immune shield for people through health education, primary care, and self-care called:"Antiviral allostasis and preventive immunostimulation.  It induces a healthy lifestyle, significantly preventing other communicable diseases and canceR.

   There is the urgent need for a change of the WHO, world and European strategy to prevent SARS_COV 2 variants risks for people health that paradoxically this kind of genetic vaccines favor because more inoculations correspond to the establishment and a proportional increase of immunodepression and exposition to cancer and neurobiological and behavioral diseases and disorders through the micro-RNA silencing.
[1] Università Ambrosiana. Medical Science and Health Paradigm Change. G.R. Brera ed: Proceedings from the Conference: Medical Science and Health Paradigm Change. Milan 13-14-15 October 2017. Internet:

[2]  Antos A, Kwong ML, Balmorez T, Villanueva A, Murakami S. Unusually High Risks of COVID-19 Mortality with Age-Related Comorbidities: An Adjusted Meta-Analysis Method to Improve the Risk Assessment of Mortality Using the Comorbid Mortality Data. Infect Dis Rep. 2021;13(3):700-711. Published 2021 August 8. doi:10.3390/idr13030065

[3] Brera G.R, Violato C Significant mortality increase in >80 anti-Sars-COV 2 vaccinated people compared to unvaccinated, a tendency in 12-39 people and the anti-covid 19 vaccines genotoxicity. Scienific Reports of the Ambosiana University Scuola Medica di Milano-Milan School of Medicine. November 16, 2021

[4]  Italian health Institute-Epicentro  Pandemic COVID-19 Updating August 18, 2021 Internet

[5]  Brera G.R Sars-Cov-2 allostasis and the people and person-centered prevention. A   new prevention strategy based on a people metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Università Ambrosiana , 2021.  ISBN: 9798530093906

[6] Brera G.R. SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The Sars-Cov 2- induced   
Immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation How to induce zero risk for covid-19. Milan:  Ambrosiana University: 2021 I ISBN: 9798547583520

[7] Erika Molteni, H. Sudre, Liane S. Canas, Sunil S. Bhopal, et al. Illness duration and symptom profile in a large cohort of symptomatic U.K. school-aged children tested for SARS-Cov-2. Lancet; 2021 

internet  file:///C:/Users/Utente/Documents/UA/ricerca/Corona%202/Illness%20duration%20and%20symptom%20profile%20in%20symptomatic%20UK%20school-aged%20children%20tested%20for%20SARS-CoV-2%20-%20The%20Lancet%20Child%20&%20Adolescent%20Health.html


[8] Byambasuren O.Cardona M.Bell al. Estimating the extent of asymptomatic COVID-19 and its potential for community    transmission: systematic review and meta-analysis. J Assoc Med Microbiol Infect Disease Canada (JAMMI). 2020; 4: 223-234

[9] Madewell ZJ, Yang Y, Longini IM, et al. Household Transmission of SARS-CoV-2. A systematic review and meta-analysis. JAMA Netw Open 2020;3(12):e2031756.doi: 10.1001/jamanetworkopen.2020.31756. 12.18.20

[10]  From the USA Center of Disease Controls and Prevention: VAERS Data about adolescents' Deaths after vaccination: 9,3 % severe adverse effects from vaccination and 14 deaths 

"    CDC reviewed 14 reports of death after vaccination. Among the decedents, four were aged 12–15 years, and 10 were aged 16–17 years. All death reports were reviewed by CDC physicians; impressions regarding the cause of death were pulmonary embolism (two), suicide (two), intracranial hemorrhage (two), heart failure (one), hemophagocytic lymphohistiocytosis and disseminated Mycobacterium chelonae infection (one), and unknown or pending further records (six).

      From CDC V-SAFe data:

   " During December 14, 2020–July 16, 2021, v-safe enrolled 66,350 adolescents aged 16–17 years who received Pfizer-BioNTech vaccine (Table 3). After Pfizer-BioNTech vaccine was authorized for adolescents aged 12–15 years (beginning May 10, 2021), v-safe enrolled 62,709 adolescents in this age group. During the week after receipt of dose 1, local (63.9%) and systemic (48.9%) reactions were commonly reported by adolescents aged 12–15 years; systemic reactions were more common after dose 2 (63.4%) than dose 1 (48.9%). Reporting trends were similar for adolescents aged 16–17 years: systemic reactions were reported among 55.7% after dose 1 and 69.9% after dose 2. For each dose and age group, reactions were reported most frequently the day after vaccination. The most frequently reported reactions for both age groups after either dose were injection site pain, fatigue, headache, and myalgia.


      During the week after receiving dose 2, approximately one-third of adolescents in both age groups reported fever. Nearly one-quarter of adolescents in both age groups reported they were unable to perform normal daily activities the day after dose 2. Fewer than 1% of adolescents aged 12–17 years required medical care in the week after receipt of either dose; 56 adolescents (0.04%) were hospitalized

[11] Brera G.R. Scientific evidence of mRNA and vectorial vaccines genotoxicity    inducingtumorsandpsycho-neuro-    behavioral disorders.
 Pre-print INTERNET 

[12]Lockhart J, Canfield J, Mong EF, Vanwye J, Rotary-Jain H. Nucleotide   Modification Alters MicroRNA-Dependent  Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019;14:339-350. doi:10.1016/j.omtn.2018.12.00

[13]  Schratt G. microRNAs at the synapse. Nat Rev Neurosci. 2009 Dec;10(12):842-9.   DOI: 10.1038/nrn2763. Epub 2009    November 4. PMID: 19888283.

[14]  Raisch J, Darfeuille-Michaud A, Nguyen HT. Role of microRNAs in the immune  system, inflammation and cancer.  World J Gastroenterol. 2013;19(20):2985-2996. doi:10.3748/wjg.v19.i20.2985

[15]   Li, T., Hu, PS., Zuo, Z. et al. METTL3 facilitates tumor progression via an m6A- IGF2BP2-dependent mechanism in  colorectal carcinoma. Mol Cancer 18, 112 (2019).

[16]  Zeng, C., Huang, W., Li, Y. et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol  13, 117 (2020).

[17] Federico M Biological and immune responses to current anti‐SARS‐ CoV‐2 mRNA vaccines beyond anti‐Spike antibody production. Proceedings 
of the Conference Person-Centered Medicine, prevention and adolescence; III° Session: Person-centered prevention, risks from genetic vaccines, early therapy of COVID-19; 2021 Nov.20 ; Milan, University Ambrosiana. 2021. p 44-45. 

[18]   Ibidem 17

[19]  Allie, S.R., Bradley, J.E., Mudunuru, U. et al. The establishment of resident memory    B cells in the lung requires local antigen encounter. Nat Immunol 20, 97–108 (2019).

[20]  Garcia-Beltran,Wilfredo F. et al  Multiple SARS-COV 2 variants escape    neutralization by vaccine-induced humoral     immunity. 2021; Cell, 184,9: 2372-2383

[21]  Israel A, Shenhar Y, Green I, et al. Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. Preprint. medRxiv. 2021;2021.08.19.21262111.

        Published 2021 August 21. doi:10.1101/2021.08.19.21262111

[22]  Federico M The conundrum of current anti-SARS-CoV-2 vaccines. Cytokine & Growth Factor Reviews.2021;60:45-61.

[23]   Doerfler W. Adenoviral Vector DNA- and SARS-Cov-2 mRNA-Based Covid-19 Vaccines: Possible Integration into   the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. DOI: 10.1016/j.virusres.2021.198466. Epub 2021 June 1. PMID: 34087261; PMCID: PMC8168329














Scientific evidence of anti -COVID 19 mRNA and vectorial  vaccines genotoxicity inducing tumors and psycho-neuro-behavioral disorders

  • November 2021


. Micro-RNAs (miR) are non-coding RNA filaments that control mRNA transcription. Micro-RNAs have been studied in cancer pathogenesis, metastasization, cancer therapy, the structuring of the central nervous system, diabetes, and heart disease.   Mir-134-138 regulate the development of dendritic spines needed for synapses. Their silencing can lead to autistic spectrum disorders and mental retardation and damage to brains in evolution such as childhood and adolescence, producing learning problems and mood problems, and in adults for alterations of receptors for neurotransmission.  It has been shown that N1-methyl pseudouridine binds to miR and induces silencing processes, increasing cell methylome at the origin of cancer. The production of mRNA vaccines replaces Uridine with N1-methyl-pseudouridine to escape innate immunity and implement rapid translation. N1-methyl-pseudouridine  binding with mi-RNA alters the epigenetic transcription of oncosuppressor that, with the increase in cell methylation, could result in the induction of tumors and relapses, natural immunity inhibition, and neuro-behavioral disorders transmissible to progeny. Vectorial vaccines hybridize the host DNA with adenoviruses and induce tumors at the experimental level. Clinical reports and long-term epidemiological investigations are necessary to verify the impact of mRNA vaccines on health.

Full text






The person-centered  paradigm change of Medical Science

 Antony S. Fauci, the USA “virostar”, and the USA Center of Disease Prevention, Rochelle Walensky, supporting Joe Biden’s decision to extend the vaccination anti-SARS 2 to children < 12 , based on a very weak Pfizer’s investigation, that does not control vaccines’ adverse effects over a long time, opened the USA doors to<12  pre-adolescents and  children’  vaccination influencing also European public health administrators.

They declared:

“The long-term effects that the people are apparently concerned about really have—with, I’m sure there is a very, very, very, very rare exception, but the long-term effects are really essentially non-existent in the sense of anything that has been a red flag on the part of the followup of these individuals. So, although one, I guess, can theoretically say I’m concerned about a long-term effect, the fact of the safety and the follow-up over now over a considerable period of time, obviously a year.(!!!! ) And so many individuals, we have just not seen that. So we don’t really see any true basis in that concern.” (Fauci)

“If all goes well, and we get the regulatory approval and the recommendation from the CDC, it’s entirely possible if not very likely that vaccines will be available for children from 5 to 11 within the first week or two of November”   (Fauci)

“We know how many parents are interested in getting their children between 5 and 11 vaccinated and we intend to act as quickly as we can” (Walensky)

The USA”virostar”,  and other world virostars, public health administrators, including those affected by “Donkey syndrome” in Italy and worldwide, should read with attention the following paper:

Lockhart L, Canfield J, Ezinne F et al. Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches. Nucleic Acids.2019;14:339-350″

Pfizer’s and Moderna’s mRNA vaccines replace uridine with N1- methyl pseudouridine to escape immunity and increase translation speed, but this substitution provokes microRNA alteration, interfering with the life survival miR silencing action. This substitution with vaccines is introduced in all the organism cells.

Adverse effects are probable (cancer-psycho-neuro-behavioral disorders) threatening over long-time children and adolescents’ health, who are not exposed to COVID-19 severity, are rarely infected, and if so, are primarily asymptomatic. Contagion risk, compared with symptomatic, is significantly reduced, as many investigations depicted.

Micro-Rna epigenetic-induced alteration by mRNA vaccines will make  very probable that the next public health problem will be the prevention of vaccine effects and treatment along with the vaccine-induced production of SARS-COV variants.  1 year is not enough to avoid concerns for life-threatening adverse effects. Leucemia could be one of these.

Concerns about  genetic adverse effects of vaccines are shared also by Luc Montagner, Medicine Nobel Prize.

A new orientation toward a person-centered health strategy is necessary primarily for children and adolescents.

Epidemiological data document that the case-fatality ratio < 29  is zero or close to zero, and inducing vaccination of children and adolescents is a crime against humanity, considering the possibility of easy and effective prevention also against other communicable and not communicable diseases through “Antiviral allostasis and preventive immunostimulation”, warranting also an immediate and natural vaccination of asymptomatic people, without adverse effects.

To date, early and effective domiciliary treatments of COVID-19 with cheap drugs already used in therapy are available, and it is possible to individuate a patient at risk of a severe clinical syndrome before the infection, allowing prevention.

Also, WHO, which suggested vaccines for > 18, (!!!!) stated:

“Children and adolescents tend to have milder disease compared to adults, so unless they are part of a group at higher risk of severe COVID-19, it is less urgent to vaccinate them than older people, those with chronic health conditions and health workers.”

The problem of mRNA induced adverse effects concerns also adults, considering the genetic and epigenetic risks which need epidemiological studies over time and worldwide and considering possibilities to prevent the infection with the antiviral allostasis and preventive immunostimulation in older people at risk of Anergy (1.2)

Moreover, we suggest to Robert Fauci and other virologists to update their fragmented and surpassed epistemologically surpassed bio-medical culture reading also these papers ( but  they do understand  the meaning of the word “epistemology”):

Federico M The conundrum of current anti-SARS-CoV-2 vaccines. Cytokine & Growth Factor Reviews.2021;60:45-61.

  Doerfler W. Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines? Virus Res. 2021 Sep;302:198466. DOI: 10.1016/j.virusres.2021.198466. Epub 2021 Jun 1. PMID: 34087261; PMCID: PMC8168329.

(Considering the DNA hybridization of vaccinated people with the chimpanzee’s DNA adenovirus by the AstraZeneca vectorial vaccine, there is the doubt that some “virostar” in the USA, in Italy, or worldwide vaccinated with Astra Zeneca could be affected by psychobiological effects of the vaccine-induced ” Chimpazee’s syndrome”. There is a simple test to be used for diagnosis: ” The banana attraction test”)  Chimpanzees do not know the meaning of the word epistemology and ethics.

We recently suggested to the USA President the change of the USA health strategy adopting the “Antiviral allostasis and preventive immunostimulation ” to avoid any risk for people otherwise damned to be persecuted by COVID-19 terrorism, health merchants, and illiterate virologists.

We suggest to those who do not know the person-centered change of medical science paradigm and the meaning of a word like “Allostasis,” the new alphabet of human physiology which revolutionized Medicine, a rapid updating.

It is necessary to understand the Person-Centered Medicine paradigm change of medical science that Fauci and other virologists and most physicians and investigators ignore.

We hope that after the recent Joe Biden’s blessing by Jorge Maria Bergoglio in the Vatican ( who also blessed vaccines as a “love act” after the signaled deaths in the USA of 14 adolescents otherwise alive), the Holy Spirit will inspire the USA President.

Giuseppe R.Brera

President of WHC and Italian Health National Committee

Director of the Ambrosiana University’s ” Scuola Medica di Milano” 


  1.  Brera G.R Sars-Cov-2 allostasis and the people and person-centered prevention. A new prevention strategy based on a people metabolic and immune shield for the pandemic shutdown. Part 1 The Sars-Cov 2 entry and COVID-19. Milan. Ambrosiana University , 2021. ISBN: 9798530093906
  1.   Brera G.R . SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The sars-cov 2- induced immunosuppression and covid-19 anergy part 3 The antiviral metabolic allostasis and preventive immunostimulation – How to induce zero risk for covid-19. Milan: Ambrosiana University: 2021 ISBN: 9798547583520




Inaugural Conference of  the 2020-2021  academic activities of Ambrosiana University



The Person-Centered Prevention Program  for pandemic prevention



Person-Centred Medicine (PCM) is the current paradigm of medical science and Medicine, and this involves the orientation of public health with a new organization of primary care and the training of doctors and students in Medicine through teachers prepared for PCM teaching. Its application, through trained doctors, allows enormous savings in suffering and costs. The PCM reconverts health to “Person-centred prevention” by promoting health education, prevention, early treatment of diseases, self-care, incentivizing individual resources, introducing and reinforcing protective factors, and buffering risk factors to improve individual resilience.
The PCM paradigm is defined as” The choice of the best possibilities for being the best human person,” which is also a political program.
In adolescence, a period of spiritual and psycho-biological formation, the PCM assumes fundamental importance throughout life because it builds an indelible trace for the future.
The Congress is held in three parts: the first is dedicated to the scientific bases of the Person-Centered Medicine interactionist and teleonomic paradigm, which will be followed by a panel dedicated to the paradigm change of Medicine. (in English) -November 13
Keynote speakers: Peter Sterling, the author of the Allostasis theory that revolutionized physiology and medical science, the fundament of the Person-Centered Medicine paradigm with other significant contributors to Medicine paradigm change .(November 13- h 15)
The second session is dedicated to adolescence. Speakers are contributors to the revolution of the paradigm of the adolescence theory. (November 13- 17,30-19,30)
The third session is dedicated to the Person-Centered Prevention paradigm, genetic and epigenetic damages induced by vaccines against SARS-COV 2, and early treatment of COVID-19.
( November 20 – h 15 in Italian-English)
Giuseppe R.Brera
Rector of the Ambrosiana University, Director of the Medical School of Milan, president of the World Health Committee and the Italian National Health Committee
Free access on zoom on registration
To give a contribution to the conference in panels (5-7′) send the enclosed abstract form to dr. Vito Galante within 7 November (1°-2° session, November 13 -3°session)





Giuseppe R.Brera

We are informed that Joe Biden, the USA President, wants to promote children and adolescents’ mRNA vaccination against SARS-COV 2.

M-RNA vaccines alter micro-RNA in any cell, and in such a way, the delicate work to silence RNA  that in the case of the epigenetic balance alteration could induce tumors and other severe pathologies. Moreover m.RNA vaccines increase the cell methylome associated with cancer. We do not know the effect of micro-RNA alterations in neurons.   Cognitive disorders, behavior alterations, and  Alzheimer’s induction could be probable. In any case, we need long-term epidemiological investigations that have been omitted by BIG-PHARMA, whose experimental trials quality has been very criticized. Micro-RNA are fundamental for health, and their alteration could be catastrophic for public health. We are underestimating the effects of epigenetic changes of mRNA vaccines on micro RNA, exposing vaccinated people to adverse effects.  A winning alternative to prevent further pandemics due to SARS-COV 2 mutation or other viruses is to promote primary and secondary prevention by inducing a natural antiviral metabolic reprogramming ( antiviral allostasis) through diet and immunostimulation  (AAVIS).  Lack of the adoption of Person-Centered change of Medicine epistemology founding the health concept intended as “The choice of the best possibilities for being the best human person,” was at the origin of the wrong strategy to cope with the pandemic’s beginning. Restrictions of human rights produced preventive effects, as Claudio Violato depicted recently, but costs for people’s mental health, work, and the economy have been high.  This strategy against human rights instituted a new health political power, like an  Orwellian culture,  but less effective than an easily accessible health education to  AAVIS, also inducing cross prevention against other communicable and non-communicable diseases like cancer.  Freedom and health are already inseparable at the experimental level, as psycho-neuro endocrine immunology depicted according to the significant contribution of Mark Laudenslager. Closing allostasis possibilities means reducing natural immunity. Freedom is the basis of a healthy allostasis,  the Sterling and Heyer’s physiology revolution forgotten by Nobel prize attribution and not yet known by almost physicians and investigators.  Allostasis is the basis of the interactionist and teleonomic person-centered revolution of the Medicine paradigm and health concept change that  WHO  omitted to formalize because of a “Donkey syndrome” pandemic. Health is relative to the interpretation quality of experience possibilities, which determines choices and lifestyle and starts from individual freedom and dignity.

Conversely, WHO and most anti-COVID 19 illiterate committees applied an outdated mechanistic conception of Medicine based on the linear causality:virus-infection –death risk while to date, the fundamental medicine paradigm is multidimensional and multifactorial based on the person-centered advances and revolution of biomedical science, primarily Allostasis, Neurobiology, Psychoneuroendocrineimmunology, Epigenetics, Affect science.  Medicine and public health must interpret any pathology as the lack of people’s health protective factors.  A public health strategy to prevent a pandemic should adopt the following multidimensional and multifactorial alphabet =  A -pathogen,  B . allostasis-C -natural immunity, D -infection risk, E disease risk, F -early therapy, G worsening risk, H death risk.  By increasing  B  and  C,  allostasis, and immunity-based people resources, we can prevent and block pandemics.  This strategy means creating a healthy lifestyle, starting from nutrition quality, education, early health care, and prevention possibilities, omitted in the SARS-COV 2 pandemic.  Without the Person-Centered  A-B-C,  the  Medicine alphabet non-known by illiterate public health officers or most virologists, any advance of biomedical science, clinical medicine, and medical education is impossible. To date, people worldwide are dependent on health merchants who want to profit from people’s diseases. They have been able to falsify scientific data like Smith&Kline in 2004, which received a penalty of 250 million dollars from the FDA. Bio-tech messianism is not the future of Medicine and public health if we want to build effective person-centered prevention.

Investigation on SARS-COV 2  depicts that there is also a limited possibility of DNA alterations.  Human DNA hybridization with heterologous  DNA  is standard with vectorial vaccines   (Astra-Seneca-Johnson). The short-term and long-term adverse effects could be hazardous because of  DNA hybridization- which is transmissible to progeny-mainly at a young age for intense immunity reactions and fatal consequences due to the closeness of corona- adenoviruses viruses infections.  (immune-complex syndrome), like occurred to a healthy girl in Italy who died after Astra-Seneca inoculation.

Moreover, what happens if the DNAs neurons of a government or public and private deans are hybridized with a chimpanzee’s DNA adenovirus or their brain is altered by mRNA vaccines. ? In Italy, healthy adolescents died because of m-RNA and Astra.Seneca vaccination-induced by government and regions’ illiterate people. We need deep and honest epidemiological investigations that BIG-PHARMA omitted. Their problem is only to sell vaccines.

 Anti-SARS-COV 2 vaccination of children and adolescents is a crime against humanity. According to epidemiology, they are not at risk of COVID-19 and asymptomatic and, if vaccinated, can be submitted to dangerous adverse effects up to death, as the USA Center for Prevention depicted. In the USA, the death of fourteen adolescents, otherwise alive, has been signaled. In the 0-29 age range, the case-fatality ratio from COVID-19 is close to zero because the young people’s natural immunity is not disturbed by cell membranes lipidic transformation as in older people, where transduction of immunity signals is altered. Inducing children and young people’s parents to authorize anti-SARS-COV vaccination is not a “Love act” as “pope” Francis written but exposes them to unuseful dangerous risks.

Moreover, the asymptomatic infection in young people promotes herd immunity like living vaccines and produces a long-lasting immunity. It is beneficial for the pandemic shutdown.  The infection ratio is half of symptomatic, and one investigation that traced 420 contacts of an asymptomatic did not find any  COVID-19.

As  President of the World Health Committee and in Italy as President of the Italian National  Health Committee, I have launched the Antiviral Allostasis and Immunostimulatory Stimulation ( AAVIS) campaign inspired by Person-Centered Medicine, the paradigm change of medical science and Medicine, which introduced the paradigm of People and Person-Centered Prevention also in the light of the formulation of the SARS-COV 2 infection relativity theory.

We started to propose AAVIS to the Russian, USA, and Romania Presidents. In Italy, we did not find an audience by a government engaged in delusional law acts introducing a people’s discrimination and control through a ” green pass” testifying a vaccination against SARS-COV 2, which does not prevent contagions but only a severe COVID-19 only in people older than 0-39.  Moreover, because of immunosenescence  in the oldest people, vaccination is effective only for a few weeks, and it requests a change of the prevention strategy toward AAVIS

Considering mRNA vaccines’ and viral vectors’ epigenetic and genetic adverse effects, respectively,  inducing a third and tomorrow more boosting is a dangerous sanitary delusion  but blessed by  BIG-PHARMA marketing plans.

Recently the Nobel Prize Luc Montagner recommended high prudence in the genetic vaccine use., confirmed by induction of genetic and epigenetic alterations.  Considering the virus’s rapid mutations like HIV, we must change preventive strategy by adopting the person-centered antiviral allostasis and immunostimulatory paradigm, which increases the freedom and responsibility-based public health, natural partner of innate immunity, superior to artificial induction of immunity from experimental vaccines with a short- time-limited immunity and adverse effects. Vaccines indeed induced a lower case/fatality ratio, but this kind of strategy, in any case, should be restricted only to people older than 29 and could induce a pandemic of adverse effects, blessed by health merchants.

SARS-COV 2  could be easily neutralizable by  AAVIS, determining a rapid and accessible shutdown of pandemic worldwide without dangerous mass vaccination and consequent adverse effects, also protecting from other pathogens and  SARS-COV 2 mutations.  AAVIS is cheap and inexpensive because founded on an effective antiviral diet and nutraceuticals. If diffused through health education could be decisive for COVID-19 and also adverse effects of vaccines prevention. AAVIS could be easily realized through media and induce cross-prevention against other communicable and non-communicable diseases like cancer.


Giuseppe R.Brera

President of the World Health Committee  and the Italian National Health Committee

Rector of the Ambrosiana University and Director of the Milan School of Medicine


Brera G.R  Medical science and health paradigm change. Milan. University Ambrosiana Editions; 2018    Internet www.

Brera G.R  Person-centered Medicine and Person-centered clinical method. Clinical results of the Medicine unitary paradigm teaching and the COVID-19 people and person-centered prevention theory. Milan. University Ambrosiana edition; 2021.   ISBN: 9798726465432

Brera G.R.  SARS-COV 2-2 allostasis and the people and person-centered prevention.

Part 1  The Sars-Cov 2 entry relativity and COVID-19. Milan.University Ambrosiana Ed. ; 2021   ISBN   9798530093906

Part 2-3  Brera G.R . SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The Sars-Cov 2- induced immunosuppression and covid-19 anergy.  Part 3 The antiviral metabolic allostasis and preventive immunostimulation  – How to induce zero risk for covid-19. Milan:  Università Ambrosiana: 2021   ISBN 9798547583520




















The “Person-centered Health relativity” and the “People and Person-Centered Prevention” theories. From epistemology to the COVID-19 pandemic shut-down.

The “Person-centered Health relativity” and the “People and Person-Centered Prevention” theories. From epistemology to the COVID-19 pandemic shut-down.


Self-Care and Well-Being in the Times of Covid-19 5 – 7 April 2021

(, promoted by the Person-Centered Medicine International College

The “Person-centered Health relativity” and the “People and Person-Centered Prevention” theories. From epistemology to the COVID-19 pandemic shut-down. [accessed Oct 04 2021].

Giuseppe R.Brera


Person-Centered Medicine (PCM) is the first extrinsic paradigm of medical science instituted due to the last forty years of advancing biomedical science and human sciences. The PCM epistemological bases are interactionism and the human nature teleonomy allowing the freedom and dignity-based “being-person” identity. The Medicine indeterministic epochal shift is similar to the discovery of quantum physics, which is allowed to constitute the “Person-centered clinical method” that integrates the obsolete one and reassesses the physician’s role as maieutic of the being person. The lecture introduces the PCM health-derived concept relativity theory and the People and Person-Centered Prevention paradigm (PPCP), whose application in the light of the SARS-COV 2 infection and complication general theory discoveries, only can shutdown the COVID-19 and other communicable and non-communicable diseases

The conundrum of current anti-SARS-CoV-2 vaccines


The conundrum of current anti-SARS-CoV-2 vaccines

Maurizio Federico


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being distributed currently, have been designed to induce neutralizing antibodies using the spike protein of the virus as an immunogen. However, the immunological correlates of protection against the virus remain unknown. This raises questions about the efficacy of current vaccination strategies. In addition, safety profiles of several vaccines seem inadequate or have not yet been evaluated under controlled experimentation. Here, evidence from the literature regarding the efforts already made to identify the immunological correlates of protection against SARS-CoV-2 infection are summarized. Furthermore, key biological features of most of the advanced vaccines and considerations regarding their safety and expected efficacy are highlighted.

Full text

Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines?

Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines?


Vigorous vaccination programs against SARS-CoV-2-causing Covid-19 are the major chance to fight this dreadful pandemic. The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into DNA, however infrequently. In some societies, people have become sensitized against the potential short- or long-term side effects of foreign DNA being injected into humans. In my laboratory, the fate of foreign DNA in mammalian (human) cells and organisms has been investigated for many years. In this review, a summary of the results obtained will be presented. This synopsis has been put in the evolutionary context of retrotransposon insertions into pre-human genomes millions of years ago. In addition, studies on adenovirus vector-based DNA, on the fate of food-ingested DNA as well as the long-term persistence of SARS-CoV-2 RNA/DNA will be described. Actual integration of viral DNA molecules and of adenovirus vector DNA will likely be chance events whose frequency and epigenetic consequences cannot with certainty be assessed. The review also addresses problems of remaining adenoviral gene expression in adenoviral-based vectors and their role in side effects of vaccines. Eventually, it will come down to weighing the possible risks of genomic insertions of vaccine-associated foreign DNA and unknown levels of vector-carried adenoviral gene expression versus protection against the dangers of Covid-19. A decision in favor of vaccination against life-threatening disease appears prudent. Informing the public about the complexities of biology will be a reliable guide when having to reach personal decisions about vaccinations.

Keywords: Adenovirus DNA integration into mammalian genomes; adenovirus vector DNA & RNA-based SARS-CoV-2 vaccines; adenovirus vector DNA integration into human genome; epigenetic consequences of foreign DNA integration; expression of adenoviral genes in vector DNA; retrotranscription of SARS-CoV-2 RNA into DNA.

Full article    



 INSTRUMENT of incorporatION

  1.  the loss of the Medicine objective ethical paradigm resulting in crimes against  human life  as abortion, euthanasia, assisted suicide, hidden mass sterilization campaigns, the political power caused loss of individual freedom based on  public health reasons, and  the omission of prevention policies only favoring the world health business;
  2.   the absence of free primary and hospital health care  for all;
  3. the biological science  and humanities Person-centered -based  paradigm change of Medicine, biomedical science, medical education named: “Person Centered Medicine” (PCM),  published in 1999, overcoming the obsolete, wrong, deterministic, mechanistic approach to clinics and prevention;[1] [2] [3]
  4. the PCM-derived  new health paradigm:” The choice of best possibilities for being the best human person” presented in WHO  on 4 May 2011;[4] [5]
  5. the world medicine and health  ethical and epistemological paradigm: “La Charte Mondial de la santé-the World Health Charter” (CMS-WHC) ;[6]
  6. the WHO and most public health national system  omission  to prevent the COVID-19 and other pandemics of communicable and non-communicable diseases  because of the ignorance about the Person-Centered Medicine paradigm and scientific ignorance responsible for millions of deaths 

The University Ambrosiana[7] Milan School of Medicine[8] , the Italian National Health Committee[9], the Person-Centered  Medicine  International Academy, the International Committee for CMS-WHC,[10] the World Federation of Adolescentology, the Italian Society of Adolescentology and Adolescence Medicine, [11] found the WORLD HEALTH COMMITTEE  (WHC)- International Committee for Health and Medicine Paradigm Change- (WCHMPC); 

  1. AIMS 
  1. The constitution of National Health Committees addressed to  institute in public health, in medical education, in biomedical research  the Person-Centered Medicine paradigm according to the ethical and epistemological paradigm of “La Charte Mondiale de la Santè-the World Health Charter” (CMS-WHC) and the Universal Declaration for Freedom and Dignity;
  2. to promote individual adhesions in countries to CMS-WHC and orient medical education to Person-Centered Medicine, Person-Centered Clinical Method and Medical Counselling and  related research according to the thriving University Ambrosiana  Milan School of Medicine quality procedures introduced in clinics and teaching since 1995[12] ;
  3. to contrast the ethical decay of Medicine resulting in abortion, assisted suicide, euthanasia  induced by physicians  who betray the Medicine meaning  and  bio-technological involution of prevention, clinical method, and research, while considering biotechnology utility, but only as a tool, not a sense;
  4. to cooperate with WHO and countries’ health ministries to orient public health to Person-Centered Medicine, to warrant possibilities for free health care for all,  and to assume as public health paradigm the health definition: “The choice for best possibilities for being the best human person.” 


  1. WHC-WCHMPC is composed of individuals who adhere to CMS-WHC (Charte Mondiale de la Santé) and the WHC-WCHMPC constitutive act, and  by health organizations that adhere to CMS-WHC ;   

The WHC- WCHMPC  members of the same country gather in Health National Committees [13](HNC) to constitute a lobby pressure on countries governments for orienting health systems to Person-Centered Medicine, and the health definition: “The choice of the best possibilities for being the best human person,” activating medical education updates, contrasting laws against rights to health and life. The Individual adhesion is formalized by an adhesion letter to CMS-WHC and the WHC-WCHMPC constitutional bill sent to  [14] The WHC-WCHMPC board members become members of the National Committees Scientific  Boards to assure coordination between- WHC –WCHMPC  governance and national Committees.

  1. Health National Committees (HNC)©, whose institution is registered by the  WHC-WCHMPC board, comprises three persons and the WHC- WHCHMPC  scientific board. The HNC  directional structure Is articulated in the following roles: President, Secretary, communication manager. Each continent gathers registered HNC. The HNC of the continent with the highest number of members represents it on the board. 
  1. WHC-WCHMPC is addressed by a board composed of prof Giuseppe R.Brera  (Italy) ( founder –President and Medical Education Director-Italy), prof. Claudio Violato  (Italy-Canada)( scientific director ) -Canada, Richard Fiordo  (USA)  ( health communication director),  Robert Cloninger (USA), George Christodoulou (Greece),   Roy Kallivayalil (India),  one delegate of HNC for each continent,  the international secretariat, and one three year delegate of adhering international health organizations.

      The  WHC-WCHMPC seat and administration are provisionally at the University Ambrosiana direction Vile Romagna 51, Milan, Italy.

     The website of WHC-WCHMPC is www. healthparadigmchange. It and the dynamic site: www. world  [15]

     International Secretariat: 

       Theoretical official textbook on PCM epistemological principles, clinical results of Person-centered clinical method teaching, and quality procedures is: “Person-Centered Medicine and Person-Centered Clinical Method”. (Giuseppe R.Brera 2021)[16]

                  Proceedings of the Conference:

   The person-centered paradigm change of health and Medicine paradigms and COVID-19[17

Promote the WHC with a donation




[1]  Brera G.R.  The manifesto of Person Centered Medicine. Medicine, Mind Adolescence ,1999; Vol. XIV, n. 1-2:3-7 Internet:

[2] Brera G R, editor . Medical Science and Health Paradigm Change. Proceedings of the Conference; 2017 Oct 13-15; Milan, It. Milano: Università Ambrosiana Ed ; 2017

[3] Brera G.R.  . Person Centered Medicine and Medical Education in third Millennium (with the introduction of Iosef Seifert  The  seven aims of Medicine it.) Roma- Pisa: IEPI ;2001 (Italian)

[4]  Brera G.R. Person Centered Medicine: Theory, Teaching, Research. Int.J.Pers. Cent.Med 2011; 1 (1):69-79

[5]  WHO symposium on Person-Centered Medicine and Medical Education :internet

[6]   La Charte Mondiale de la Santé-the World Health Charter   Internet






[12] Brera G.R  Person-Centered Medicine and Person Centered Clinical Method. Clinical results of the Medicine unitary paradigm   teaching and the the SARS-COV 2 entry relativity theory inducing COVID-19 person-centered prevention. Milan; University Ambrosiana editions; 2021

[13]To date, the first National Committee to date is the Italian National Health Committee.

[14] WCHMP members can upload: “ Medical science and health paradigm change” from

[15] In edition within 10 August 2021

[16] Ibidem 7

[17] Ibidem 13