Inaugural Conference of the 2020-2021 academic activities of Ambrosiana University
PERSON-CENTERED MEDICINE, PREVENTION
AND ADOLESCENCE.
The Person-Centered Prevention Program for pandemic prevention
Introduction
Inaugural Conference of the 2020-2021 academic activities of Ambrosiana University
PERSON-CENTERED MEDICINE, PREVENTION
AND ADOLESCENCE.
The Person-Centered Prevention Program for pandemic prevention
Introduction
OPEN LETTER TO WASHINGTON POST
Giuseppe R.Brera
We are informed that Joe Biden, the USA President, wants to promote children and adolescents’ mRNA vaccination against SARS-COV 2.
M-RNA vaccines alter micro-RNA in any cell, and in such a way, the delicate work to silence RNA that in the case of the epigenetic balance alteration could induce tumors and other severe pathologies. Moreover m.RNA vaccines increase the cell methylome associated with cancer. We do not know the effect of micro-RNA alterations in neurons. Cognitive disorders, behavior alterations, and Alzheimer’s induction could be probable. In any case, we need long-term epidemiological investigations that have been omitted by BIG-PHARMA, whose experimental trials quality has been very criticized. Micro-RNA are fundamental for health, and their alteration could be catastrophic for public health. We are underestimating the effects of epigenetic changes of mRNA vaccines on micro RNA, exposing vaccinated people to adverse effects. A winning alternative to prevent further pandemics due to SARS-COV 2 mutation or other viruses is to promote primary and secondary prevention by inducing a natural antiviral metabolic reprogramming ( antiviral allostasis) through diet and immunostimulation (AAVIS). Lack of the adoption of Person-Centered change of Medicine epistemology founding the health concept intended as “The choice of the best possibilities for being the best human person,” was at the origin of the wrong strategy to cope with the pandemic’s beginning. Restrictions of human rights produced preventive effects, as Claudio Violato depicted recently, but costs for people’s mental health, work, and the economy have been high. This strategy against human rights instituted a new health political power, like an Orwellian culture, but less effective than an easily accessible health education to AAVIS, also inducing cross prevention against other communicable and non-communicable diseases like cancer. Freedom and health are already inseparable at the experimental level, as psycho-neuro endocrine immunology depicted according to the significant contribution of Mark Laudenslager. Closing allostasis possibilities means reducing natural immunity. Freedom is the basis of a healthy allostasis, the Sterling and Heyer’s physiology revolution forgotten by Nobel prize attribution and not yet known by almost physicians and investigators. Allostasis is the basis of the interactionist and teleonomic person-centered revolution of the Medicine paradigm and health concept change that WHO omitted to formalize because of a “Donkey syndrome” pandemic. Health is relative to the interpretation quality of experience possibilities, which determines choices and lifestyle and starts from individual freedom and dignity.
Conversely, WHO and most anti-COVID 19 illiterate committees applied an outdated mechanistic conception of Medicine based on the linear causality:virus-infection –death risk while to date, the fundamental medicine paradigm is multidimensional and multifactorial based on the person-centered advances and revolution of biomedical science, primarily Allostasis, Neurobiology, Psychoneuroendocrineimmunology, Epigenetics, Affect science. Medicine and public health must interpret any pathology as the lack of people’s health protective factors. A public health strategy to prevent a pandemic should adopt the following multidimensional and multifactorial alphabet = A -pathogen, B . allostasis-C -natural immunity, D -infection risk, E disease risk, F -early therapy, G worsening risk, H death risk. By increasing B and C, allostasis, and immunity-based people resources, we can prevent and block pandemics. This strategy means creating a healthy lifestyle, starting from nutrition quality, education, early health care, and prevention possibilities, omitted in the SARS-COV 2 pandemic. Without the Person-Centered A-B-C, the Medicine alphabet non-known by illiterate public health officers or most virologists, any advance of biomedical science, clinical medicine, and medical education is impossible. To date, people worldwide are dependent on health merchants who want to profit from people’s diseases. They have been able to falsify scientific data like Smith&Kline in 2004, which received a penalty of 250 million dollars from the FDA. Bio-tech messianism is not the future of Medicine and public health if we want to build effective person-centered prevention.
Investigation on SARS-COV 2 depicts that there is also a limited possibility of DNA alterations. Human DNA hybridization with heterologous DNA is standard with vectorial vaccines (Astra-Seneca-Johnson). The short-term and long-term adverse effects could be hazardous because of DNA hybridization- which is transmissible to progeny-mainly at a young age for intense immunity reactions and fatal consequences due to the closeness of corona- adenoviruses viruses infections. (immune-complex syndrome), like occurred to a healthy girl in Italy who died after Astra-Seneca inoculation.
Moreover, what happens if the DNAs neurons of a government or public and private deans are hybridized with a chimpanzee’s DNA adenovirus or their brain is altered by mRNA vaccines. ? In Italy, healthy adolescents died because of m-RNA and Astra.Seneca vaccination-induced by government and regions’ illiterate people. We need deep and honest epidemiological investigations that BIG-PHARMA omitted. Their problem is only to sell vaccines.
Anti-SARS-COV 2 vaccination of children and adolescents is a crime against humanity. According to epidemiology, they are not at risk of COVID-19 and asymptomatic and, if vaccinated, can be submitted to dangerous adverse effects up to death, as the USA Center for Prevention depicted. In the USA, the death of fourteen adolescents, otherwise alive, has been signaled. In the 0-29 age range, the case-fatality ratio from COVID-19 is close to zero because the young people’s natural immunity is not disturbed by cell membranes lipidic transformation as in older people, where transduction of immunity signals is altered. Inducing children and young people’s parents to authorize anti-SARS-COV vaccination is not a “Love act” as “pope” Francis written but exposes them to unuseful dangerous risks.
Moreover, the asymptomatic infection in young people promotes herd immunity like living vaccines and produces a long-lasting immunity. It is beneficial for the pandemic shutdown. The infection ratio is half of symptomatic, and one investigation that traced 420 contacts of an asymptomatic did not find any COVID-19.
As President of the World Health Committee and in Italy as President of the Italian National Health Committee, I have launched the Antiviral Allostasis and Immunostimulatory Stimulation ( AAVIS) campaign inspired by Person-Centered Medicine, the paradigm change of medical science and Medicine, which introduced the paradigm of People and Person-Centered Prevention also in the light of the formulation of the SARS-COV 2 infection relativity theory.
We started to propose AAVIS to the Russian, USA, and Romania Presidents. In Italy, we did not find an audience by a government engaged in delusional law acts introducing a people’s discrimination and control through a ” green pass” testifying a vaccination against SARS-COV 2, which does not prevent contagions but only a severe COVID-19 only in people older than 0-39. Moreover, because of immunosenescence in the oldest people, vaccination is effective only for a few weeks, and it requests a change of the prevention strategy toward AAVIS
Considering mRNA vaccines’ and viral vectors’ epigenetic and genetic adverse effects, respectively, inducing a third and tomorrow more boosting is a dangerous sanitary delusion but blessed by BIG-PHARMA marketing plans.
Recently the Nobel Prize Luc Montagner recommended high prudence in the genetic vaccine use., confirmed by induction of genetic and epigenetic alterations. Considering the virus’s rapid mutations like HIV, we must change preventive strategy by adopting the person-centered antiviral allostasis and immunostimulatory paradigm, which increases the freedom and responsibility-based public health, natural partner of innate immunity, superior to artificial induction of immunity from experimental vaccines with a short- time-limited immunity and adverse effects. Vaccines indeed induced a lower case/fatality ratio, but this kind of strategy, in any case, should be restricted only to people older than 29 and could induce a pandemic of adverse effects, blessed by health merchants.
SARS-COV 2 could be easily neutralizable by AAVIS, determining a rapid and accessible shutdown of pandemic worldwide without dangerous mass vaccination and consequent adverse effects, also protecting from other pathogens and SARS-COV 2 mutations. AAVIS is cheap and inexpensive because founded on an effective antiviral diet and nutraceuticals. If diffused through health education could be decisive for COVID-19 and also adverse effects of vaccines prevention. AAVIS could be easily realized through media and induce cross-prevention against other communicable and non-communicable diseases like cancer.
Giuseppe R.Brera
President of the World Health Committee and the Italian National Health Committee
Rector of the Ambrosiana University and Director of the Milan School of Medicine
References
Brera G.R Medical science and health paradigm change. Milan. University Ambrosiana Editions; 2018 Internet www. healthparadigmchange.it
Brera G.R Person-centered Medicine and Person-centered clinical method. Clinical results of the Medicine unitary paradigm teaching and the COVID-19 people and person-centered prevention theory. Milan. University Ambrosiana edition; 2021. ISBN: 9798726465432
Brera G.R. SARS-COV 2-2 allostasis and the people and person-centered prevention.
Part 1 The Sars-Cov 2 entry relativity and COVID-19. Milan.University Ambrosiana Ed. ; 2021 ISBN 9798530093906
Part 2-3 Brera G.R . SARS-COV 2- allostasis and the people and person-centered prevention. Part 2 The Sars-Cov 2- induced immunosuppression and covid-19 anergy. Part 3 The antiviral metabolic allostasis and preventive immunostimulation – How to induce zero risk for covid-19. Milan: Università Ambrosiana: 2021 ISBN 9798547583520
Presentation at the VIRTUAL 13th GENEVA CONFERENCE ON PERSON-CENTERED MEDICINE
Self-Care and Well-Being in the Times of Covid-19 5 – 7 April 2021
(, promoted by the Person-Centered Medicine International College
The “Person-centered Health relativity” and the “People and Person-Centered Prevention” theories. From epistemology to the COVID-19 pandemic shut-down.
https://www.researchgate.net/publication/351617577_The_Person-centered_Health_relativity_and_the_People_and_Person-Centered_Prevention_theories_From_epistemology_to_the_COVID-19_pandemic_shut-down [accessed Oct 04 2021].
Abstract
Maurizio Federico
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being distributed currently, have been designed to induce neutralizing antibodies using the spike protein of the virus as an immunogen. However, the immunological correlates of protection against the virus remain unknown. This raises questions about the efficacy of current vaccination strategies. In addition, safety profiles of several vaccines seem inadequate or have not yet been evaluated under controlled experimentation. Here, evidence from the literature regarding the efforts already made to identify the immunological correlates of protection against SARS-CoV-2 infection are summarized. Furthermore, key biological features of most of the advanced vaccines and considerations regarding their safety and expected efficacy are highlighted.
Vigorous vaccination programs against SARS-CoV-2-causing Covid-19 are the major chance to fight this dreadful pandemic. The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into DNA, however infrequently. In some societies, people have become sensitized against the potential short- or long-term side effects of foreign DNA being injected into humans. In my laboratory, the fate of foreign DNA in mammalian (human) cells and organisms has been investigated for many years. In this review, a summary of the results obtained will be presented. This synopsis has been put in the evolutionary context of retrotransposon insertions into pre-human genomes millions of years ago. In addition, studies on adenovirus vector-based DNA, on the fate of food-ingested DNA as well as the long-term persistence of SARS-CoV-2 RNA/DNA will be described. Actual integration of viral DNA molecules and of adenovirus vector DNA will likely be chance events whose frequency and epigenetic consequences cannot with certainty be assessed. The review also addresses problems of remaining adenoviral gene expression in adenoviral-based vectors and their role in side effects of vaccines. Eventually, it will come down to weighing the possible risks of genomic insertions of vaccine-associated foreign DNA and unknown levels of vector-carried adenoviral gene expression versus protection against the dangers of Covid-19. A decision in favor of vaccination against life-threatening disease appears prudent. Informing the public about the complexities of biology will be a reliable guide when having to reach personal decisions about vaccinations.
Keywords: Adenovirus DNA integration into mammalian genomes; adenovirus vector DNA & RNA-based SARS-CoV-2 vaccines; adenovirus vector DNA integration into human genome; epigenetic consequences of foreign DNA integration; expression of adenoviral genes in vector DNA; retrotranscription of SARS-CoV-2 RNA into DNA.
Copyright © 2021. Published by Elsevier B.V.
Full article
The University Ambrosiana[7] Milan School of Medicine[8] , the Italian National Health Committee[9], the Person-Centered Medicine International Academy, the International Committee for CMS-WHC,[10] the World Federation of Adolescentology, the Italian Society of Adolescentology and Adolescence Medicine, [11] found the WORLD HEALTH COMMITTEE (WHC)- International Committee for Health and Medicine Paradigm Change- (WCHMPC);
3 WHC-WCHMPC STRUCTURE AND ADHESION
The WHC- WCHMPC members of the same country gather in Health National Committees [13](HNC) to constitute a lobby pressure on countries governments for orienting health systems to Person-Centered Medicine, and the health definition: “The choice of the best possibilities for being the best human person,” activating medical education updates, contrasting laws against rights to health and life. The Individual adhesion is formalized by an adhesion letter to CMS-WHC and the WHC-WCHMPC constitutional bill sent to adhesion@healthparadigmchange.it [14] The WHC-WCHMPC board members become members of the National Committees Scientific Boards to assure coordination between- WHC –WCHMPC governance and national Committees.
The WHC-WCHMPC seat and administration are provisionally at the University Ambrosiana direction Vile Romagna 51, Milan, Italy.
The website of WHC-WCHMPC is www. healthparadigmchange. It and the dynamic site: www. world healthcommittee.net [15]
International Secretariat: secretariat@healthparadigmchange.it
Theoretical official textbook on PCM epistemological principles, clinical results of Person-centered clinical method teaching, and quality procedures is: “Person-Centered Medicine and Person-Centered Clinical Method”. (Giuseppe R.Brera 2021)[16]
Proceedings of the Conference:
The person-centered paradigm change of health and Medicine paradigms and COVID-19[17
Promote the WHC with a donation
[1] Brera G.R. The manifesto of Person Centered Medicine. Medicine, Mind Adolescence ,1999; Vol. XIV, n. 1-2:3-7 Internet: https://www.unambro.it/html/manifesto.htm
[2] Brera G R, editor . Medical Science and Health Paradigm Change. Proceedings of the Conference; 2017 Oct 13-15; Milan, It. Milano: Università Ambrosiana Ed ; 2017
[3] Brera G.R. . Person Centered Medicine and Medical Education in third Millennium (with the introduction of Iosef Seifert The seven aims of Medicine it.) Roma- Pisa: IEPI ;2001 (Italian)
[4] Brera G.R. Person Centered Medicine: Theory, Teaching, Research. Int.J.Pers. Cent.Med 2011; 1 (1):69-79
[5] WHO symposium on Person-Centered Medicine and Medical Education :internet
[6] La Charte Mondiale de la Santé-the World Health Charter Internet
[7] www.unambro.it
[8] www.scuolamedicamilano.it
[9] www.comitatosanitarionazionale.it
[10] www.healthparadigmchange.it
[11] www.adolescentologia.it
[12] Brera G.R Person-Centered Medicine and Person Centered Clinical Method. Clinical results of the Medicine unitary paradigm teaching and the the SARS-COV 2 entry relativity theory inducing COVID-19 person-centered prevention. Milan; University Ambrosiana editions; 2021
[13]To date, the first National Committee to date is the Italian National Health Committee. www.comitatosanitariopnazionle.it
[14] WCHMP members can upload: “ Medical science and health paradigm change” from www.healthpardigmchange.it
[15] In edition within 10 August 2021
[16] Ibidem 7
[17] Ibidem 13