Month: September 2021

The conundrum of current anti-SARS-CoV-2 vaccines

 

The conundrum of current anti-SARS-CoV-2 vaccines

Maurizio Federico

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being distributed currently, have been designed to induce neutralizing antibodies using the spike protein of the virus as an immunogen. However, the immunological correlates of protection against the virus remain unknown. This raises questions about the efficacy of current vaccination strategies. In addition, safety profiles of several vaccines seem inadequate or have not yet been evaluated under controlled experimentation. Here, evidence from the literature regarding the efforts already made to identify the immunological correlates of protection against SARS-CoV-2 infection are summarized. Furthermore, key biological features of most of the advanced vaccines and considerations regarding their safety and expected efficacy are highlighted.

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Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines?

Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome – Are Adenoviral Genes Expressed in Vector-based Vaccines?

Walter Doerfler 1

Abstract

Vigorous vaccination programs against SARS-CoV-2-causing Covid-19 are the major chance to fight this dreadful pandemic. The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into DNA, however infrequently. In some societies, people have become sensitized against the potential short- or long-term side effects of foreign DNA being injected into humans. In my laboratory, the fate of foreign DNA in mammalian (human) cells and organisms has been investigated for many years. In this review, a summary of the results obtained will be presented. This synopsis has been put in the evolutionary context of retrotransposon insertions into pre-human genomes millions of years ago. In addition, studies on adenovirus vector-based DNA, on the fate of food-ingested DNA as well as the long-term persistence of SARS-CoV-2 RNA/DNA will be described. Actual integration of viral DNA molecules and of adenovirus vector DNA will likely be chance events whose frequency and epigenetic consequences cannot with certainty be assessed. The review also addresses problems of remaining adenoviral gene expression in adenoviral-based vectors and their role in side effects of vaccines. Eventually, it will come down to weighing the possible risks of genomic insertions of vaccine-associated foreign DNA and unknown levels of vector-carried adenoviral gene expression versus protection against the dangers of Covid-19. A decision in favor of vaccination against life-threatening disease appears prudent. Informing the public about the complexities of biology will be a reliable guide when having to reach personal decisions about vaccinations.

Keywords: Adenovirus DNA integration into mammalian genomes; adenovirus vector DNA & RNA-based SARS-CoV-2 vaccines; adenovirus vector DNA integration into human genome; epigenetic consequences of foreign DNA integration; expression of adenoviral genes in vector DNA; retrotranscription of SARS-CoV-2 RNA into DNA.

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WELCOME TO THE WORLD HEALTH COMMITTEE

 

 INSTRUMENT of incorporatION

  1. IN THE LIGHT Of
  1.  the loss of the Medicine objective ethical paradigm resulting in crimes against  human life  as abortion, euthanasia, assisted suicide, hidden mass sterilization campaigns, the political power caused loss of individual freedom based on  public health reasons, and  the omission of prevention policies only favoring the world health business;
  2.   the absence of free primary and hospital health care  for all;
  3. the biological science  and humanities Person-centered -based  paradigm change of Medicine, biomedical science, medical education named: “Person Centered Medicine” (PCM),  published in 1999, overcoming the obsolete, wrong, deterministic, mechanistic approach to clinics and prevention;[1] [2] [3]
  4. the PCM-derived  new health paradigm:” The choice of best possibilities for being the best human person” presented in WHO  on 4 May 2011;[4] [5]
  5. the world medicine and health  ethical and epistemological paradigm: “La Charte Mondial de la santé-the World Health Charter” (CMS-WHC) ;[6]
  6. the WHO and most public health national system  omission  to prevent the COVID-19 and other pandemics of communicable and non-communicable diseases  because of the ignorance about the Person-Centered Medicine paradigm and scientific ignorance responsible for millions of deaths 

The University Ambrosiana[7] Milan School of Medicine[8] , the Italian National Health Committee[9], the Person-Centered  Medicine  International Academy, the International Committee for CMS-WHC,[10] the World Federation of Adolescentology, the Italian Society of Adolescentology and Adolescence Medicine, [11] found the WORLD HEALTH COMMITTEE  (WHC)- International Committee for Health and Medicine Paradigm Change- (WCHMPC); 

  1. AIMS 
  1. The constitution of National Health Committees addressed to  institute in public health, in medical education, in biomedical research  the Person-Centered Medicine paradigm according to the ethical and epistemological paradigm of “La Charte Mondiale de la Santè-the World Health Charter” (CMS-WHC) and the Universal Declaration for Freedom and Dignity;
  2. to promote individual adhesions in countries to CMS-WHC and orient medical education to Person-Centered Medicine, Person-Centered Clinical Method and Medical Counselling and  related research according to the thriving University Ambrosiana  Milan School of Medicine quality procedures introduced in clinics and teaching since 1995[12] ;
  3. to contrast the ethical decay of Medicine resulting in abortion, assisted suicide, euthanasia  induced by physicians  who betray the Medicine meaning  and  bio-technological involution of prevention, clinical method, and research, while considering biotechnology utility, but only as a tool, not a sense;
  4. to cooperate with WHO and countries’ health ministries to orient public health to Person-Centered Medicine, to warrant possibilities for free health care for all,  and to assume as public health paradigm the health definition: “The choice for best possibilities for being the best human person.” 

3   WHC-WCHMPC STRUCTURE AND ADHESION 

  1. WHC-WCHMPC is composed of individuals who adhere to CMS-WHC (Charte Mondiale de la Santé) and the WHC-WCHMPC constitutive act, and  by health organizations that adhere to CMS-WHC ;   

The WHC- WCHMPC  members of the same country gather in Health National Committees [13](HNC) to constitute a lobby pressure on countries governments for orienting health systems to Person-Centered Medicine, and the health definition: “The choice of the best possibilities for being the best human person,” activating medical education updates, contrasting laws against rights to health and life. The Individual adhesion is formalized by an adhesion letter to CMS-WHC and the WHC-WCHMPC constitutional bill sent to  adhesion@healthparadigmchange.it  [14] The WHC-WCHMPC board members become members of the National Committees Scientific  Boards to assure coordination between- WHC –WCHMPC  governance and national Committees.

  1. Health National Committees (HNC)©, whose institution is registered by the  WHC-WCHMPC board, comprises three persons and the WHC- WHCHMPC  scientific board. The HNC  directional structure Is articulated in the following roles: President, Secretary, communication manager. Each continent gathers registered HNC. The HNC of the continent with the highest number of members represents it on the board. 
  1. WHC-WCHMPC is addressed by a board composed of prof Giuseppe R.Brera  (Italy) ( founder –President and Medical Education Director-Italy), prof. Claudio Violato  (Italy-Canada)( scientific director ) -Canada, Richard Fiordo  (USA)  ( health communication director),  Robert Cloninger (USA), George Christodoulou (Greece),   Roy Kallivayalil (India),  one delegate of HNC for each continent,  the international secretariat, and one three year delegate of adhering international health organizations.

      The  WHC-WCHMPC seat and administration are provisionally at the University Ambrosiana direction Vile Romagna 51, Milan, Italy.

     The website of WHC-WCHMPC is www. healthparadigmchange. It and the dynamic site: www. world healthcommittee.net  [15]

     International Secretariat:    secretariat@healthparadigmchange.it 

       Theoretical official textbook on PCM epistemological principles, clinical results of Person-centered clinical method teaching, and quality procedures is: “Person-Centered Medicine and Person-Centered Clinical Method”. (Giuseppe R.Brera 2021)[16]

                  Proceedings of the Conference:

   The person-centered paradigm change of health and Medicine paradigms and COVID-19[17

Promote the WHC with a donation

 

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[1]  Brera G.R.  The manifesto of Person Centered Medicine. Medicine, Mind Adolescence ,1999; Vol. XIV, n. 1-2:3-7 Internet: https://www.unambro.it/html/manifesto.htm

[2] Brera G R, editor . Medical Science and Health Paradigm Change. Proceedings of the Conference; 2017 Oct 13-15; Milan, It. Milano: Università Ambrosiana Ed ; 2017

[3] Brera G.R.  . Person Centered Medicine and Medical Education in third Millennium (with the introduction of Iosef Seifert  The  seven aims of Medicine it.) Roma- Pisa: IEPI ;2001 (Italian)

[4]  Brera G.R. Person Centered Medicine: Theory, Teaching, Research. Int.J.Pers. Cent.Med 2011; 1 (1):69-79

[5]  WHO symposium on Person-Centered Medicine and Medical Education :internet

[6]   La Charte Mondiale de la Santé-the World Health Charter   Internet

[7] www.unambro.it

[8] www.scuolamedicamilano.it

[9] www.comitatosanitarionazionale.it

[10] www.healthparadigmchange.it

[11] www.adolescentologia.it

[12] Brera G.R  Person-Centered Medicine and Person Centered Clinical Method. Clinical results of the Medicine unitary paradigm   teaching and the the SARS-COV 2 entry relativity theory inducing COVID-19 person-centered prevention. Milan; University Ambrosiana editions; 2021

[13]To date, the first National Committee to date is the Italian National Health Committee. www.comitatosanitariopnazionle.it

[14] WCHMP members can upload: “ Medical science and health paradigm change” from www.healthpardigmchange.it

[15] In edition within 10 August 2021

[16] Ibidem 7

[17] Ibidem 13

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